KD025 ( SLx-2119; SLx2119; SLx 2119; KD 025 )

产品货号. M19254 CAS No. 911417-87-3

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Datasheet

HNMR

HPLC

MSDS

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产品名称

KD025
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

KD025 is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).
产品描述

SLx-2119, also known as KD-025, is an orally bioavailable inhibitor of ROCK-II that is greater than 200-fold selective over ROCK-I (IC50s = 105 nM and 24 μM, respectively).
同义词

SLx-2119; SLx2119; SLx 2119; KD 025
通路

Others
靶点

Other Targets
受体

ROCK2; ROCK2
研究领域

Cancer
适应症

——

CAS Number

911417-87-3
分子量

452.51
分子式

C26H24N6O2
纯度

98%
溶解度

DMSO : ≥ 29 mg/mL; 64.09 mM
SMILES

C(=O)(COc1cc(ccc1)c1nc2c(c(n1)Nc1cc3cn[nH]c3cc1)cccc2)NC(C)C
化学全称

2-[3-[4-(1H-indazol-5-ylamino)-2-quinazolinyl]phenoxy]-N-(1-methylethyl)-acetamide

1. Lee JH, et al. Ann Clin Transl Neurol. 2014, 1(1), 2-14.

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