K-975
CAS No. 2563855-03-6
K-975 ( —— )
产品货号. M28980 CAS No. 2563855-03-6
K-975 is a highly selective, orally active TEAD inhibitor, effectively inhibiting protein-protein interactions between TEAD and YAP1/TAZ.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥1320 | 有现货 |
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10MG | ¥2130 | 有现货 |
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25MG | ¥4277 | 有现货 |
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50MG | ¥6051 | 有现货 |
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100MG | 获取报价 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称K-975
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述K-975 is a highly selective, orally active TEAD inhibitor, effectively inhibiting protein-protein interactions between TEAD and YAP1/TAZ.
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产品描述K-975 is a highly selective, orally active TEAD inhibitor, effectively inhibiting protein-protein interactions between TEAD and YAP1/TAZ.(In Vitro):K-975 inhibits the cell proliferation of NRF2-non-expressing malignant pleural mesothelioma (MPM) cell lines, protein-protein interaction (PPI) between Halo-TAZ and TEAD1/4 and Halo-YAP and endogenous TEAD1/4 in NCl-H226 cells and the reporter activity in NCl-H661/CTGF-Luc cells with the maximum of ~70%, at concentration of 0.1-10000 nM at 144 h and 24 h, respectively . K-975 decreases the expression of IGFBP3, CTGF and NPPB mRNAs, and increases the expression of FBXO32 mRNA in NCl-H226 cells .(In Vivo):K-975 (10-300 mg/kg; p.o. twice a day for 14 days) suppresses the growth of tumors via inhibiting TEAD-YAP1/TAZ signaling in MPM xenograft mouse models .
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同义词——
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number2563855-03-6
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分子量287.7
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分子式C16H14ClNO2
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纯度>98% (HPLC)
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溶解度——
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SMILESCC1=CC=C(NC(=O)C=C)C=C1OC1=CC=C(Cl)C=C1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Fuller RW, Mason NR, Molloy BB. Structural relationships in the inhibition of [(3)H]serotonin binding to rat brain membranes in vitro by 1-phenyl-piperazines. Biochem Pharmacol. 1980 Mar 1;29(5):833-5.
产品手册
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