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K-604
CAS No. 217094-32-1
K-604 ( K604 )
产品货号. M13469 CAS No. 217094-32-1
K-604 is a potent, selective and competitive ACAT-1 inhibitor with IC50 of 0.45 uM for human ACAT-1, displays 229-fold selectivity over ACAT-2.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥599 | 有现货 |
|
| 5MG | ￥988 | 有现货 |
|
| 10MG | ￥1596 | 有现货 |
|
| 25MG | ￥3216 | 有现货 |
|
| 50MG | ￥4771 | 有现货 |
|
| 100MG | ￥6828 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称K-604
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述K-604 is a potent, selective and competitive ACAT-1 inhibitor with IC50 of 0.45 uM for human ACAT-1, displays 229-fold selectivity over ACAT-2.
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产品描述K-604 is a potent, selective and competitive ACAT-1 inhibitor with IC50 of 0.45 uM for human ACAT-1, displays 229-fold selectivity over ACAT-2; inhibits cholesterol esterification in human monocyte-derived macrophages with IC50 of 60 nM, enhances cholesterol efflux from THP-1 macrophages to HDL3 or apolipoprotein A-I; suppresses the development of atherosclerosis in an animal model without affecting plasma cholesterol levels.Atherosclerosis Phase 2 Clinical
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同义词K604
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通路Others
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靶点Other Targets
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受体Other Targets
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研究领域Cardiovascular Disease
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适应症Atherosclerosis
化学信息
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CAS Number217094-32-1
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分子量575.63
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分子式C23H32Cl2N6OS3
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纯度>98% (HPLC)
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溶解度——
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SMILESCC1=CC(=C(C(=N1)SC)NC(=O)CN2CCN(CC2)CCSC3=NC4=CC=CC=C4N3)SC.Cl.Cl
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化学全称4-[2-(1H-Benzimidazol-2-ylthio)ethyl]-N-[6-methyl-2,4-bis(methylthio)-3-pyridinyl]-1-piperazineacetamide dihydrochloride
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Ikenoya M, et al. Atherosclerosis. 2007 Apr;191(2):290-7.
2. Shibuya Y, et al. J Neurosci. 2014 Oct 22;34(43):14484-501.
3. Yoshinaka Y, et al. Atherosclerosis. 2010 Nov;213(1):85-91.
2. Shibuya Y, et al. J Neurosci. 2014 Oct 22;34(43):14484-501.
3. Yoshinaka Y, et al. Atherosclerosis. 2010 Nov;213(1):85-91.
产品手册
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