021-51111890
购物车（）
sales@molnova.cn
K-604
CAS No. 217094-32-1
K-604 ( K604 )
产品货号. M13469 CAS No. 217094-32-1
K-604 is a potent, selective and competitive ACAT-1 inhibitor with IC50 of 0.45 uM for human ACAT-1, displays 229-fold selectivity over ACAT-2.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥599 | 有现货 |
|
| 5MG | ￥988 | 有现货 |
|
| 10MG | ￥1596 | 有现货 |
|
| 25MG | ￥3216 | 有现货 |
|
| 50MG | ￥4771 | 有现货 |
|
| 100MG | ￥6828 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称K-604
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述K-604 is a potent, selective and competitive ACAT-1 inhibitor with IC50 of 0.45 uM for human ACAT-1, displays 229-fold selectivity over ACAT-2.
-
产品描述K-604 is a potent, selective and competitive ACAT-1 inhibitor with IC50 of 0.45 uM for human ACAT-1, displays 229-fold selectivity over ACAT-2; inhibits cholesterol esterification in human monocyte-derived macrophages with IC50 of 60 nM, enhances cholesterol efflux from THP-1 macrophages to HDL3 or apolipoprotein A-I; suppresses the development of atherosclerosis in an animal model without affecting plasma cholesterol levels.Atherosclerosis Phase 2 Clinical
-
同义词K604
-
通路Others
-
靶点Other Targets
-
受体Other Targets
-
研究领域Cardiovascular Disease
-
适应症Atherosclerosis
化学信息
-
CAS Number217094-32-1
-
分子量575.63
-
分子式C23H32Cl2N6OS3
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESCC1=CC(=C(C(=N1)SC)NC(=O)CN2CCN(CC2)CCSC3=NC4=CC=CC=C4N3)SC.Cl.Cl
-
化学全称4-[2-(1H-Benzimidazol-2-ylthio)ethyl]-N-[6-methyl-2,4-bis(methylthio)-3-pyridinyl]-1-piperazineacetamide dihydrochloride
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Ikenoya M, et al. Atherosclerosis. 2007 Apr;191(2):290-7.
2. Shibuya Y, et al. J Neurosci. 2014 Oct 22;34(43):14484-501.
3. Yoshinaka Y, et al. Atherosclerosis. 2010 Nov;213(1):85-91.
2. Shibuya Y, et al. J Neurosci. 2014 Oct 22;34(43):14484-501.
3. Yoshinaka Y, et al. Atherosclerosis. 2010 Nov;213(1):85-91.
产品手册
关联产品
-
AZD5904
AZD5904 (AZD-5904) is a potent, selective irreversible, orally bioavailable myeloperoxidase (MPO) inhibitor with IC50 of 140 nM.
-
Quercetin 3,4-digluc...
Quercetin 3,4'-diglucoside possesses antioxidant activities.
-
Isoformononetin
Isoformononetin shows fungitoxic activity against Cladosporium sphaerospermum; it also has immunomodulatory activity, it inhibits the differentiation of Th17 cells and B-cell lymphopoesis to promote osteogenesis in estrogen-deficient bone loss conditions.
