Jervine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened.

The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and Hedgehog target genes cannot be transcribed.

11-Ketocyclopamine

Others

Other Targets

Hedgehog; Smoothened

Cancer

——

469-59-0

425.61

C27H39NO3

98%

DMSO : 1 mg/mL2.35 mM;

O=C1C2=C(C)[C@]3(CC[C@H]2[C@@H]2CC=C4C[C@H](CC[C@]4(C)[C@@H]12)O)O[C@@H]1C[C@@H](CN[C@H]1[C@H]3C)C

——

(-20℃)

With Ice Pack

≥ 2 years