Jervine ( 11-Ketocyclopamine )

产品货号. M17515 CAS No. 469-59-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Jervine
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Jervine 的生物活性是通过其与 7 次跨膜蛋白 Smoothened 的相互作用介导的。 Jevine 结合并抑制平滑。
产品描述

The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and Hedgehog target genes cannot be transcribed.
体外实验

Jervine (40 μM; 6, 12 and 24 hours) inhibits Akt phosphorylation. Jervine (40 μM; 2 hours) inhibits NF-jB activation decreased COX-2 overexpression and induced apoptosis. Western Blot Analysis Cell Line:HEL and TF1a cells Concentration:40 μM Incubation Time:6, 12 and 24 hours Result:Inhibited Akt phosphorylation.
体内实验

Jervine (orally; 50-400 mg/kg) exerts 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema. Animal Model:Male Sprague Dawley rats (180-200? g)Dosage:50, 100, 200 and 400? mg/kg Administration:Orally Result:Exerted 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema.
同义词

11-Ketocyclopamine
通路

Others
靶点

Other Targets
受体

Hedgehog| Smoothened
研究领域

Cancer
适应症

——

CAS Number

469-59-0
分子量

425.61
分子式

C27H39NO3
纯度

>98% (HPLC)
溶解度

DMSO : 1 mg/mL2.35 mM;
SMILES

O=C1C2=C(C)[C@]3(CC[C@H]2[C@@H]2CC=C4C[C@H](CC[C@]4(C)[C@@H]12)O)O[C@@H]1C[C@@H](CN[C@H]1[C@H]3C)C
化学全称

——

1. Chen JK, et al. Genes Dev. 2002 Nov 1; 16(21): 2743–2748.

计算器

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