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Jervine
CAS No. 469-59-0
Jervine ( 11-Ketocyclopamine )
产品货号. M17515 CAS No. 469-59-0
The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened.
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥518 | 有现货 |
|
| 10MG | ￥988 | 有现货 |
|
| 25MG | ￥2211 | 有现货 |
|
| 50MG | ￥4253 | 有现货 |
|
| 100MG | ￥6099 | 有现货 |
|
| 500MG | ￥12312 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Jervine
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened.
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产品描述The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and Hedgehog target genes cannot be transcribed.
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同义词11-Ketocyclopamine
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通路Others
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靶点Other Targets
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受体Hedgehog; Smoothened
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研究领域Cancer
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适应症——
化学信息
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CAS Number469-59-0
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分子量425.61
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分子式C27H39NO3
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纯度98%
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溶解度DMSO : 1 mg/mL2.35 mM;
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SMILESO=C1C2=C(C)[C@]3(CC[C@H]2[C@@H]2CC=C4C[C@H](CC[C@]4(C)[C@@H]12)O)O[C@@H]1C[C@@H](CN[C@H]1[C@H]3C)C
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Chen JK, et al. Genes Dev. 2002 Nov 1; 16(21): 2743–2748.
