
JZL184
CAS No. 1101854-58-3
JZL184 ( JZL184 | JZL 184 | JZL-184 )
产品货号. M17810 CAS No. 1101854-58-3
JZL 184 是一种有效的选择性 MAGL 抑制剂,抑制小鼠脑膜中的 MAGL 和 FAAH 的 IC50 分别为 8 nM 和 4 μM。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥275 | 有现货 |
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10MG | ¥437 | 有现货 |
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25MG | ¥940 | 有现货 |
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50MG | ¥1774 | 有现货 |
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100MG | ¥3216 | 有现货 |
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200MG | ¥4334 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称JZL184
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述JZL 184 是一种有效的选择性 MAGL 抑制剂,抑制小鼠脑膜中的 MAGL 和 FAAH 的 IC50 分别为 8 nM 和 4 μM。
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产品描述JZL184 is highly selective, and potent MAGL inhibitor ( monoacylglycerol lipase inhibitor). JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome. JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action. JZL184 also suppresses inflammatory pain in the mouse carrageenan model.
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体外实验JZL 184 displays IC50 values of 8 nM and 4 μM for blockade of 2-AG and oleamide (FAAH substrate) hydrolysis in brain membranes, respectively. Comparable inhibitory effects are observed with recombinant MAGL and FAAH when expressed in COS7 cells.
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体内实验JZL 184 (4-40 mg/kg; intraperitoneal injection; once; C57Bl/6 mice) treatment produces a rapid and sustained blockade of brain 2-AG hydrolase activity in mice, resulting in 8-fold elevations in endogenous 2-AG levels that are maintained for at least 8 h. JZL 184-treated mice shows a remarkable array of CB1-dependent behavioral effects, including analgesia, hypomotility, and hypothermia.JZL 184 prolongs depolarization-induced suppression of excitation (DSE) in Purkinje neurons in cerebellar slices and DSE inhibition (DSI) in CA1 pyramidal neurons in hippocampal slices. JZL 184 produces greater enhancement of DSE/DSI in mouse neurons than that in rat neurons. Animal Model:Male C57Bl/6 mice (6-8 weeks old, 20-26 g) Dosage:4 mg/kg, 8 mg/kg, 16 mg/kg, 40 mg/kg Administration:Intraperitoneal injection; once Result:Produced a rapid and sustained blockade of brain 2-AG hydrolase activity in mice, resulting in 8-fold elevations in endogenous 2-AG levels that were maintained for at least 8 h.
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同义词JZL184 | JZL 184 | JZL-184
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通路Others
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靶点Other Targets
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受体MAGL
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研究领域Neurological Disease
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适应症——
化学信息
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CAS Number1101854-58-3
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分子量520.49
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分子式C27H24N2O9
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纯度>98% (HPLC)
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溶解度DMSO : ≥ 35 mg/mL; 67.24 mM
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SMILESOC(C1CCN(CC1)C(=O)Oc1ccc(cc1)[N+](=O)[O-])(c1ccc2OCOc2c1)c1ccc2OCOc2c1
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化学全称4-nitrophenyl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate.
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Long JZ, et al. Nat Chem Biol, 2009, 5(1), 37-44.
产品手册




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