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JZL184

CAS No. 1101854-58-3

JZL184 ( JZL184 | JZL 184 | JZL-184 )

产品货号. M17810 CAS No. 1101854-58-3

JZL 184 是一种有效的选择性 MAGL 抑制剂,抑制小鼠脑膜中的 MAGL 和 FAAH 的 IC50 分别为 8 nM 和 4 μM。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥275 有现货
10MG ¥437 有现货
25MG ¥940 有现货
50MG ¥1774 有现货
100MG ¥3216 有现货
200MG ¥4334 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    JZL184
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    JZL 184 是一种有效的选择性 MAGL 抑制剂,抑制小鼠脑膜中的 MAGL 和 FAAH 的 IC50 分别为 8 nM 和 4 μM。
  • 产品描述
    JZL184 is highly selective, and potent MAGL inhibitor ( monoacylglycerol lipase inhibitor). JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome. JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action. JZL184 also suppresses inflammatory pain in the mouse carrageenan model.
  • 体外实验
    JZL 184 displays IC50 values of 8 nM and 4 μM for blockade of 2-AG and oleamide (FAAH substrate) hydrolysis in brain membranes, respectively. Comparable inhibitory effects are observed with recombinant MAGL and FAAH when expressed in COS7 cells.
  • 体内实验
    JZL 184 (4-40 mg/kg; intraperitoneal injection; once; C57Bl/6 mice) treatment produces a rapid and sustained blockade of brain 2-AG hydrolase activity in mice, resulting in 8-fold elevations in endogenous 2-AG levels that are maintained for at least 8 h. JZL 184-treated mice shows a remarkable array of CB1-dependent behavioral effects, including analgesia, hypomotility, and hypothermia.JZL 184 prolongs depolarization-induced suppression of excitation (DSE) in Purkinje neurons in cerebellar slices and DSE inhibition (DSI) in CA1 pyramidal neurons in hippocampal slices. JZL 184 produces greater enhancement of DSE/DSI in mouse neurons than that in rat neurons. Animal Model:Male C57Bl/6 mice (6-8 weeks old, 20-26 g) Dosage:4 mg/kg, 8 mg/kg, 16 mg/kg, 40 mg/kg Administration:Intraperitoneal injection; once Result:Produced a rapid and sustained blockade of brain 2-AG hydrolase activity in mice, resulting in 8-fold elevations in endogenous 2-AG levels that were maintained for at least 8 h.
  • 同义词
    JZL184 | JZL 184 | JZL-184
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    MAGL
  • 研究领域
    Neurological Disease
  • 适应症
    ——

化学信息

  • CAS Number
    1101854-58-3
  • 分子量
    520.49
  • 分子式
    C27H24N2O9
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : ≥ 35 mg/mL; 67.24 mM
  • SMILES
    OC(C1CCN(CC1)C(=O)Oc1ccc(cc1)[N+](=O)[O-])(c1ccc2OCOc2c1)c1ccc2OCOc2c1
  • 化学全称
    4-nitrophenyl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate.

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Long JZ, et al. Nat Chem Biol, 2009, 5(1), 37-44.
产品手册
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