JR-AB2-011

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

JR-AB2-011 通过阻断 Rictor-mTOR 关联来抑制 mTORC2 活性（Ki：0.19 μM）。 JR-AB2-011 具有抗多形性胶质母细胞瘤 (GBM) 特性。

JR-AB2-011 inhibits mTORC2 activity by blocking Rictor-mTOR association (Ki: 0.19 μM). JR-AB2-011 has anti-glioblastoma multiforme (GBM) properties. JR-AB2-011 is a selective mTORC2 inhibitor with an IC50 value of 0.36 μM. JR-AB2-011 (0.5-2 μM; 48 hours) displays the least toxicity to normal neurons with no significant cytotoxic effects for concentrations up to 10 mM compared to CID613034.JR-AB2-011 (1 μM; 24 hours) has good anti-GBM properties, blocks mTORC2 signaling and Rictor association with mTOR. JR-AB2-011 at 20 mg/kg/d; 80% inhibition at end of dosing period; tumor growth delay 12.0 days) as compared to mice receiving vehicle alone.Mice receiving JR-AB2-011 (4 mg/kg; daily i.p. for 10 days; 20 mg/kg; daily i.p. for 10 days) at either dosing regimen display marked inhibition of tumor growth rate (JR-AB2-011 at 4 mg/kg/d; 74% inhibition at end of dosing period; tumor growth delay 10.0 days.

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PI3K/Akt/mTOR signaling

mTOR

mTORC2

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329182-61-8

398.28

C17H14Cl2FN3OS

>98% (HPLC)

DMSO:61.5 mg/mL(154.41 mM)

CC1CN=C(S1)N(C(=O)Nc1ccc(Cl)c(Cl)c1)c1ccc(F)cc1

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(-20℃)

With Ice Pack

≥ 2 years