JNJ-42905343 ( JNJ 42905343 | JNJ42905343 )

产品货号. M10958 CAS No. 1238689-36-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

JNJ-42905343
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

JNJ-42905343 是一种有效的、选择性的、口服活性的脯氨酰羟化酶 (PHD) 抑制剂。
产品描述

JNJ-42905343 is a potent, selective, orally active prolyl hydroxylase (PHD) inhibitor with pKi of 8.07, 7.48 and 7.27 for PHD1, PHD2 and PHD3 respectively; stabilizes HIF1-α in a concentration-dependent fashion in HeLa cells (EC50=19.7 uM) and stimulates the release of EPO from Hep3B cells (EC50=20.3 uM); increases blood haemoglobin, mean corpuscular haemoglobin (MCH) and mean corpuscular volume (MCV), corrects functional iron deficiency and inflammation-induced anaemia in rats.
体外实验

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体内实验

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同义词

JNJ 42905343 | JNJ42905343
通路

Angiogenesis
靶点

HIF/HIF Prolyl-hydroxylase
受体

HIF/HIF Prolyl-hydroxylase
研究领域

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适应症

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CAS Number

1238689-36-5
分子量

394.362
分子式

C20H15FN4O4
纯度

>98% (HPLC)
溶解度

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SMILES

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化学全称

1-(6-(2,6-dimethylphenoxy)-7-fluoro-4-oxo-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylic acid