JNJ-31020028 ( JNJ31020028 | JNJ 31020028 | JNJ-31020028 )

产品货号. M10369 CAS No. 1094873-14-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

产品询价大包装询价加入购物车

产品名称

JNJ-31020028
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

JNJ-31020028是一种高亲和力的神经肽Y2受体选择性脑渗透拮抗剂（pIC50=8.07，人；pIC50=8.22大鼠）。
产品描述

JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22 rat); >100-fold selective versus human Y1/Y4/Y5 receptors.
体外实验

JNJ-31020028 (0-10 μM) selectively binds with hY2 , rY2 and mY2 with pIC50 values of 8.07, 8.22 and 8.21, respectively.JNJ-31020028 (0.1 nM-10 μM; 1 hour) inhibits PYY-induced calcium response with a pKB value of 8.04.
体内实验

JNJ-31020028 (0-20 mg/kg; s.c. once) affects the level of plasma corticosterone and refeeding result in stressed animals. Animal Model:Stressed and nonstressed male Sprague-Dawley ratsDosage:0, 3, 10 and 20 mg/kg Administration:Subcutaneous injection; 0-20 mg/kg once Result:Significantly decreased plasma corticosterone levels in stressed animals, but not significantly affected plasma corticosterone levels in nonstressed animals. Attenuated effects of stress on refeeding.
同义词

JNJ31020028 | JNJ 31020028 | JNJ-31020028
通路

Others
靶点

Other Targets
受体

Y2 receptor
研究领域

Neurological Disease
适应症

——

CAS Number

1094873-14-9
分子量

565.68
分子式

C34H36FN5O2
纯度

>98% (HPLC)
溶解度

DMSO: 10 mM
SMILES

O=C(NC1=CC=C(N2CCN(C(C3=CC=CC=C3)C(N(CC)CC)=O)CC2)C(F)=C1)C4=CC=CC=C4C5=CC=CN=C5
化学全称

N-(4-(4-(2-(diethylamino)-2-oxo-1-phenylethyl)piperazin-1-yl)-3-fluorophenyl)-2-(pyridin-3-yl)benzamide

1.Shoblock JR, et al. Psychopharmacology (Berl). 2010 Feb;208(2):265-77.

计算器

产品手册

关联产品

(R)-Carisbamate

(R)-Carisbamate 是 Carisbamate 的 R 异构体。 Carisbamate 是一种实验性抗惊厥化合物。
TNF-α (46-65), human

Human TNF alpha (46-65) peptide.
Chrysene

Chrysene 是一种高分子量 (HMW) 多环芳烃 (PAH)。