JI-101 ( JI101, JI 101, JI-101 )

产品货号. M17651 CAS No. 900573-88-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

JI-101
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

JI-101 is an oral multi-kinase inhibitor that targets vascular endothelial growth factor receptor type 2 (VEGFR-2), platelet derived growth factor receptor β (PDGFR-β), and ephrin type-B receptor 4 (EphB4).
产品描述

JI-101 is an orally active inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor beta (PDGFRb), and the ephrin B4 receptor B4 (EphB4) with potential antiangiogenic and antineoplastic activities. Angiogenesis inhibitor JI-101 binds to and inhibits VEGFR2, PDGFRb and EphB4, which may inhibit tumor angiogenesis and, so, cellular proliferation in tumor cells overexpressing VEGFR2, PDGFRb and EphB4. The receptor tyrosine kinases VEGFR2, PDGFRb and EphB4 may be overexpressed in a number of different cancer cell types and may play crucial roles in tumor angiogenesis.
同义词

JI101, JI 101, JI-101
通路

Others
靶点

Other Targets
受体

Ephrin Receptor; PDGFR; VEGFR
研究领域

Cardiovascular Disease
适应症

——

CAS Number

900573-88-8
分子量

466.34
分子式

C22H20BrN5O2
纯度

98%
溶解度

DMSO : ≥ 100 mg/mL; 214.44 mM
SMILES

N(C(=O)Nc1c(ccc(c1)Br)OC)c1c2ccn(c2ccc1)Cc1cc(ncc1)N
化学全称

1-(1-((2-aminopyridin-4-yl)methyl)-1H-indol-4-yl)-3-(5-bromo-2-methoxyphenyl)urea.

1.Mark L. Wade, Neeraj Agarwal et al. Investigational New Drugs, December 2015, Volume 33, Issue 6, pp 1217-1224

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