JH-VIII-157-02 ( JH-VIII-157-02; JH-VIII-15702; JH-VIII-157 02; JHVIII-157-02 )

产品货号. M12480 CAS No. 1639422-97-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

JH-VIII-157-02
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

JH-VIII-157-02 is a potent, orally active, CNS-permeable, second-generation inhibitor of ALK G1202R mutant with IC50 of 2 nM.
产品描述

JH-VIII-157-02 is a potent, orally active, CNS-permeable, second-generation inhibitor of ALK G1202R mutant with IC50 of 2 nM, also shows high potency against a variety of other frequently observed mutants (G1269A, S1206Y, F1174L and C1156Y); inhibits EML4-ALKWT with IC50 of 2 nM, demonstrates inhibition of CSNK2A1 <10 uM, IRAK1 (IC50 =14 nM), IRAK4 with (IC50=465 nM), CLK4 (IC50=14 nM), RET (IC50=3 nM), RET V804L (IC50=13 nM); potently inhibits proliferation of NSCLC H3122 cell line with IC50 of 5 nM.
同义词

JH-VIII-157-02; JH-VIII-15702; JH-VIII-157 02; JHVIII-157-02
通路

Angiogenesis
靶点

ALK
受体

ALK
研究领域

Cancer
适应症

——

CAS Number

1639422-97-1
分子量

465.56
分子式

C28H27N5O2
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 25 mg/mL 53.70 mM
SMILES

O=C(N(C)C)CN1N=CC(C2=C(CC)C=C3C(C(C)(C)C(NC4=C5C=CC(C#N)=C4)=C5C3=O)=C2)=C1
化学全称

2-(4-(3-cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)-1H-pyrazol-1-yl)-N,N-dimethylacetamide

1. Hatcher JM, et al. J Med Chem. 2015 Dec 10;58(23):9296-9308.
2. Wang H, et al. Drug Des Devel Ther. 2018 May 9;12:1183-1193.

计算器

产品手册

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