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JC-1

CAS No. 3520-43-2

JC-1 ( CBIC2 )

产品货号. M22703 CAS No. 3520-43-2

JC-1 is a fluorescent lipophilic carbocyanine dye. It has been used to measure mitochondrial membrane potential.?JC 1 can be used in a probe for measuring mitochondrial membrane potential by flow cytometry. JC-1 fluorescence is usually excited by the 488?nm laser wavelength common in flow cytometers. JC-1 (2.5?μM) exposed to murine L1210 lymphoblasts, can be detected the presence of both cytoplasmic JC-1 monomer and mitochondrial J-aggregates in these cells.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥656 有现货
5MG ¥1239 有现货
10MG ¥2041 有现货
25MG ¥3426 有现货
50MG ¥5087 有现货
100MG ¥7233 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    JC-1
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    JC-1 is a fluorescent lipophilic carbocyanine dye. It has been used to measure mitochondrial membrane potential.?JC 1 can be used in a probe for measuring mitochondrial membrane potential by flow cytometry. JC-1 fluorescence is usually excited by the 488?nm laser wavelength common in flow cytometers. JC-1 (2.5?μM) exposed to murine L1210 lymphoblasts, can be detected the presence of both cytoplasmic JC-1 monomer and mitochondrial J-aggregates in these cells.
  • 产品描述
    JC-1 is a fluorescent lipophilic carbocyanine dye. It has been used to measure mitochondrial membrane potential.?JC 1 can be used in a probe for measuring mitochondrial membrane potential by flow cytometry. JC-1 fluorescence is usually excited by the 488?nm laser wavelength common in flow cytometers. JC-1 (2.5?μM) exposed to murine L1210 lymphoblasts, can be detected the presence of both cytoplasmic JC-1 monomer and mitochondrial J-aggregates in these cells. Fluorescent labeling of mitochondria with either JC-1 (1 μg/mL, 15 min), reveals that are distributed irregularly, resulting in regions of high and low mitochondrial content within astrocytes. JC-1 is avidly accumulated in sensitive K562 cells where it displays both a green cytoplasmic and red mitochondrial fluorescence. JC-1 is poorly accumulated in resistant K562 cells, which displays only a slight green fluorescence. JC-1 has been shown to interact with α-synuclein at the acidic C-terminal region with a Kd of 2.6 μM. JC-1 itself does not accelerate the protein aggregation of α-synuclein in the absence of iron, insted, it decelerates the aggregation process by extending the lag phase approx.
  • 同义词
    CBIC2
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    3520-43-2
  • 分子量
    652.23
  • 分子式
    C25H27Cl4IN4
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO:14 mg/mL(21.46 mM)
  • SMILES
    [I-].CCN1\C(=C/C=C/c2n(CC)c3cc(Cl)c(Cl)cc3[n+]2CC)N(CC)c2cc(Cl)c(Cl)cc12
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. A Perelman, et al. JC-1: alternative excitation wavelengths facilitate mitochondrial membrane potential cytometry. Cell Death Dis. 2012 Nov 22;3:e430.
产品手册
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