JC-1
CAS No. 3520-43-2
JC-1 ( CBIC2 )
产品货号. M22703 CAS No. 3520-43-2
JC-1 is a fluorescent lipophilic carbocyanine dye. It has been used to measure mitochondrial membrane potential.?JC 1 can be used in a probe for measuring mitochondrial membrane potential by flow cytometry. JC-1 fluorescence is usually excited by the 488?nm laser wavelength common in flow cytometers. JC-1 (2.5?μM) exposed to murine L1210 lymphoblasts, can be detected the presence of both cytoplasmic JC-1 monomer and mitochondrial J-aggregates in these cells.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥656 | 有现货 |
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5MG | ¥1239 | 有现货 |
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10MG | ¥2041 | 有现货 |
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25MG | ¥3426 | 有现货 |
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50MG | ¥5087 | 有现货 |
|
100MG | ¥7233 | 有现货 |
|
200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
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生物学信息
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产品名称JC-1
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述JC-1 is a fluorescent lipophilic carbocyanine dye. It has been used to measure mitochondrial membrane potential.?JC 1 can be used in a probe for measuring mitochondrial membrane potential by flow cytometry. JC-1 fluorescence is usually excited by the 488?nm laser wavelength common in flow cytometers. JC-1 (2.5?μM) exposed to murine L1210 lymphoblasts, can be detected the presence of both cytoplasmic JC-1 monomer and mitochondrial J-aggregates in these cells.
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产品描述JC-1 is a fluorescent lipophilic carbocyanine dye. It has been used to measure mitochondrial membrane potential.?JC 1 can be used in a probe for measuring mitochondrial membrane potential by flow cytometry. JC-1 fluorescence is usually excited by the 488?nm laser wavelength common in flow cytometers. JC-1 (2.5?μM) exposed to murine L1210 lymphoblasts, can be detected the presence of both cytoplasmic JC-1 monomer and mitochondrial J-aggregates in these cells. Fluorescent labeling of mitochondria with either JC-1 (1 μg/mL, 15 min), reveals that are distributed irregularly, resulting in regions of high and low mitochondrial content within astrocytes. JC-1 is avidly accumulated in sensitive K562 cells where it displays both a green cytoplasmic and red mitochondrial fluorescence. JC-1 is poorly accumulated in resistant K562 cells, which displays only a slight green fluorescence. JC-1 has been shown to interact with α-synuclein at the acidic C-terminal region with a Kd of 2.6 μM. JC-1 itself does not accelerate the protein aggregation of α-synuclein in the absence of iron, insted, it decelerates the aggregation process by extending the lag phase approx.
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同义词CBIC2
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number3520-43-2
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分子量652.23
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分子式C25H27Cl4IN4
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纯度>98% (HPLC)
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溶解度DMSO:14 mg/mL(21.46 mM)
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SMILES[I-].CCN1\C(=C/C=C/c2n(CC)c3cc(Cl)c(Cl)cc3[n+]2CC)N(CC)c2cc(Cl)c(Cl)cc12
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. A Perelman, et al. JC-1: alternative excitation wavelengths facilitate mitochondrial membrane potential cytometry. Cell Death Dis. 2012 Nov 22;3:e430.
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