
JBSNF-000088
CAS No. 7150-23-4
JBSNF-000088 ( JBSNF 000088 | JBSNF000088 )
产品货号. M24726 CAS No. 7150-23-4
JBSNF-000088 是一种烟酰胺 N-甲基转移酶 (NNMT) 抑制剂。它用于治疗代谢紊乱。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
100MG | ¥316 | 有现货 |
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200MG | ¥446 | 有现货 |
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500MG | ¥737 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称JBSNF-000088
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述JBSNF-000088 是一种烟酰胺 N-甲基转移酶 (NNMT) 抑制剂。它用于治疗代谢紊乱。
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产品描述JBSNF-000088 is an Nicotinamide N-methyltransferase (NNMT)inhibitor. It is used for the treatment of metabolic disorders.
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体外实验——
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体内实验Animal Model:Mice with high fat diet (HFD)-induced obesityDosage:50?mg/kg Administration:Oral route of administration for four weeks; oral gavage administration and twice daily for four weeks Result:Showed statistically significant reduction in body weight (%) and led to a statistically significant reduction in fed blood glucose on day 21 by oral route of administration. Led to a statistically significant improvement in oral glucose tolerance on day 28 with glucose tolerance being normalized by oral gavage administration.Animal Model:C57BL/6 mice Dosage:1 mg/kg (Intravenous administration);10 mg/kg (oral gavage)(Pharmacokinetic Study)Administration:Intravenous administration and oral gavage; for 4 hours Result:Resulted in low plasma clearance of 21?mL/min?kg and the volume of distribution at steady state of 0.7?L/kg, a very short plasma half-life of 0.5?h upon intravenous administration.Resulted in a Cmax of 3568 ng/mL with a Tmax value of 0.5?hours, indicating rapid absorption in the intestine, and half-life of 0.4?hours by oral gavage.
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同义词JBSNF 000088 | JBSNF000088
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通路Others
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靶点Other Targets
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受体NNMT
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研究领域——
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适应症——
化学信息
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CAS Number7150-23-4
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分子量152.15
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分子式C7H8N2O2
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纯度>98% (HPLC)
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溶解度DMSO:100 mg/mL (657.25 mM)
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SMILESO=C(N)C1=CN=C(OC)C=C1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Kannt A, Rajagopal S, Kadnur SV, Suresh J, Bhamidipati RK, Swaminathan S, Hallur MS, Kristam R, Elvert R, Czech J, Pfenninger A, Rudolph C, Schreuder H, Chandrasekar DV, Mane VS, Birudukota S, Shaik S, Zope BR, Burri RR, Anand NN, Thakur MK, Singh M, Parveen R, Kandan S, Mullangi R, Yura T, Gosu R, Ruf S, Dhakshinamoorthy S. A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders. Sci Rep. 2018 Feb 26;8(1):3660. doi: 10.1038/s41598-018-22081-7.
产品手册




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