
Isorhamnetin
CAS No. 480-19-3
Isorhamnetin ( 3'-O-methyl Quercetin )
产品货号. M14602 CAS No. 480-19-3
Isorhamnetin 是从中草药沙棘 (Hippophae rhamnoides L.) 中提取的类黄酮化合物。Isorhamnetin 可通过直接抑制 MEK1 和 PI3K 来抑制皮肤癌。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥608 | 有现货 |
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10MG | ¥988 | 有现货 |
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25MG | ¥2001 | 有现货 |
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50MG | ¥3345 | 有现货 |
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100MG | ¥4779 | 有现货 |
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500MG | ¥10287 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Isorhamnetin
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Isorhamnetin 是从中草药沙棘 (Hippophae rhamnoides L.) 中提取的类黄酮化合物。Isorhamnetin 可通过直接抑制 MEK1 和 PI3K 来抑制皮肤癌。
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产品描述Red turnip,goldenrod,mustard leaf,ginkgo biloba.(In Vitro):Isorhamnetin is a plant flavonoid that occurs in fruits and medicinal herbs. Isorhamnetin binds directly to MEK1 in an ATP-noncompetitive manner and to PI3-K in an ATP-competitive manner. In vitro and ex vivo kinase assay data show that Isorhamnetin inhibits the kinase activity of MAP/ERK kinase (MEK) 1 and PI3-K and the inhibition is due to direct binding with Isorhamnetin. Isorhamnetin inhibits the Akt/mTOR and MEK/ERK signaling pathways, and promotes the activity of the mitochondrial apoptosis signaling pathway. The inhibitory effects of Isorhamnetin on breast cancer cells are determined using the CCK-8 method. Isorhamnetin inhibits the proliferation of numerous breast cancer cells (IC50, ~10 μM), including MCF7, T47D, BT474, BT-549, MDA-MB-231 and MDA-MB-468, whereas less inhibitory activity is observed in the MCF10A normal breast epithelial cell line (IC50, 38 μM).(In Vivo):Photographic data shows that Isorhamnetin treatment suppresses tumor development in mice. The average volume of tumors in untreated mice increases over time and reaches a volume of 623 mm3 at 4 weeks post-inoculation; however, at this time, in mice treated with 1 or 5 mg/kg Isorhamnetin, the average tumor volume is only 280 or 198 mm3, respectively. At the end of the study, Isorhamnetin treatment (1 or 5 mg/kg) reduces tumor weight compared with the untreated control group.
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体外实验——
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体内实验——
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同义词3'-O-methyl Quercetin
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通路Others
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靶点Other Targets
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受体Others
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研究领域Other Indications
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适应症——
化学信息
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CAS Number480-19-3
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分子量316.27
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分子式C16H12O7
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纯度>98% (HPLC)
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溶解度DMSO: 10 mM
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SMILESO=C1C(O)=C(C2=CC=C(O)C(OC)=C2)OC3=CC(O)=CC(O)=C13
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化学全称3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Han X, et al. Biomol Ther (Seoul). 2015 Jul;23(4):357-66.
产品手册




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