Isolongifolene
CAS No. 1135-66-6
Isolongifolene ( (-)-Isolongifolene )
产品货号. M23324 CAS No. 1135-66-6
异长叶烯具有抗氧化、抗炎、抗癌和神经保护特性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥883 | 有现货 |
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10MG | ¥1312 | 有现货 |
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25MG | ¥2179 | 有现货 |
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50MG | ¥3224 | 有现货 |
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100MG | 获取报价 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Isolongifolene
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述异长叶烯具有抗氧化、抗炎、抗癌和神经保护特性。
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产品描述Isolongifolene has antioxidant, anti-inflammatory, anticancer and neuroprotective properties. Isolongifolene is a tricyclic sesquiterpene isolated from Murraya koenigii. Isolongifolene attenuates Rotenone-induced oxidative stress, mitochondrial dysfunction and apoptosis through the regulation of P13K/AKT/GSK-3β signaling pathways.
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体外实验Isolongifolene (0-50 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment significantly alleviates Rotenone-induced cytotoxicity in SH-SY5Y cells in a dose-dependent manner.Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone-induced apoptosis in SH-SY5Y cells.Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Furthermore regulation of p-P13K, p-AKT and p-GSK-3β expression by Isolongifolene. Cell Viability Assay Cell Line:SH-SY5Y neuroblastoma cells Concentration:0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM and 50 μM Incubation Time:26 hours Result:Significantly alleviated Rotenone-induced cytotoxicity in SH-SY5Y cells.Apoptosis Analysis Cell Line:SH-SY5Y neuroblastoma cells Concentration:10 μMIncubation Time:26 hours Result:Attenuated Rotenone-induced apoptosis in SH-SY5Y cells.Western Blot AnalysisCell Line:SH-SY5Y neuroblastoma cells Concentration:10 μM Incubation Time:26 hours Result:Attenuated rotenone induced toxicity by down-regulatingBax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Prevented the rotenone-induced decreased phosphorylation of GSK-3β.
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体内实验——
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同义词(-)-Isolongifolene
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number1135-66-6
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分子量204.35
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分子式C15H24
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纯度>98% (HPLC)
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溶解度DMSO:10 mM
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SMILESCC1(C)[C@]23CC[C@](C3)([H])C(C)(C)C2=CCC1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Balakrishnan R, et al. Isolongifolene attenuates rotenone-induced mitochondrial dysfunction, oxidative stress and apoptosis. Front Biosci (Schol Ed). 2018 Jan 1;10:248-261.
产品手册
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