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Isolongifolene

CAS No. 1135-66-6

Isolongifolene ( (-)-Isolongifolene )

产品货号. M23324 CAS No. 1135-66-6

异长叶烯具有抗氧化、抗炎、抗癌和神经保护特性。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥883 有现货
10MG ¥1312 有现货
25MG ¥2179 有现货
50MG ¥3224 有现货
100MG 获取报价 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Isolongifolene
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    异长叶烯具有抗氧化、抗炎、抗癌和神经保护特性。
  • 产品描述
    Isolongifolene has antioxidant, anti-inflammatory, anticancer and neuroprotective properties. Isolongifolene is a tricyclic sesquiterpene isolated from Murraya koenigii. Isolongifolene attenuates Rotenone-induced oxidative stress, mitochondrial dysfunction and apoptosis through the regulation of P13K/AKT/GSK-3β signaling pathways.
  • 体外实验
    Isolongifolene (0-50 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment significantly alleviates Rotenone-induced cytotoxicity in SH-SY5Y cells in a dose-dependent manner.Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone-induced apoptosis in SH-SY5Y cells.Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Furthermore regulation of p-P13K, p-AKT and p-GSK-3β expression by Isolongifolene. Cell Viability Assay Cell Line:SH-SY5Y neuroblastoma cells Concentration:0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM and 50 μM Incubation Time:26 hours Result:Significantly alleviated Rotenone-induced cytotoxicity in SH-SY5Y cells.Apoptosis Analysis Cell Line:SH-SY5Y neuroblastoma cells Concentration:10 μMIncubation Time:26 hours Result:Attenuated Rotenone-induced apoptosis in SH-SY5Y cells.Western Blot AnalysisCell Line:SH-SY5Y neuroblastoma cells Concentration:10 μM Incubation Time:26 hours Result:Attenuated rotenone induced toxicity by down-regulatingBax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Prevented the rotenone-induced decreased phosphorylation of GSK-3β.
  • 体内实验
    ——
  • 同义词
    (-)-Isolongifolene
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1135-66-6
  • 分子量
    204.35
  • 分子式
    C15H24
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO:10 mM
  • SMILES
    CC1(C)[C@]23CC[C@](C3)([H])C(C)(C)C2=CCC1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Balakrishnan R, et al. Isolongifolene attenuates rotenone-induced mitochondrial dysfunction, oxidative stress and apoptosis. Front Biosci (Schol Ed). 2018 Jan 1;10:248-261.
产品手册
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