
Isbufylline
CAS No. 90162-60-0
Isbufylline ( —— )
产品货号. M28920 CAS No. 90162-60-0
除支气管扩张活性外,异丁茶碱还可发挥显着的抗炎作用。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥3540 | 有现货 |
![]() ![]() |
10MG | ¥5233 | 有现货 |
![]() ![]() |
25MG | ¥7995 | 有现货 |
![]() ![]() |
50MG | ¥11178 | 有现货 |
![]() ![]() |
100MG | ¥15066 | 有现货 |
![]() ![]() |
500MG | ¥30132 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称Isbufylline
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述除支气管扩张活性外,异丁茶碱还可发挥显着的抗炎作用。
-
产品描述Isbufylline can exert significant anti-inflammatory actions, in addition to its bronchodilator activity.(In Vivo):At a dose (106 μmol/kg i.p.) providing complete protection against acetylcholine aerosol-induced dyspnea in the guinea pig, Isbufylline inhibited platelet-activating factor (PAF)- and antigen-induced eosinophil infiltration into bronchoalveolar lavage fluid 24 h after the challenge of normal and actively immunized guinea pigs, respectively. In addition, this dose of Isbufylline also inhibited capsaicin-induced extravasation of protein into bronchoalveolar lavage fluid. Isbufylline, 4.2 μmol/kg i.v., significantly inhibited PAF-induced bronchial hyper-responsiveness to i.v. histamine, without exerting evident bronchodilator activity. On the other hand, the bronchodilator, salbutamol, at a dose (10.4 μmol/kg i.p.) was shown to be equieffective to Isbufylline (106 μmol/kg i.p.) for blocking acetylcholine aerosol-induced dyspnea, had no protective action against PAF- or antigen-induced eosinophil recruitment in bronchoalveolar lavage fluid, or against capsaicin-induced plasma protein extravasation. Furthermore, salbutamol (3.5 μmol/kg) significantly potentiated allergen-induced cell infiltration and PAF-induced bronchial hyperresponsiveness.
-
体外实验——
-
体内实验——
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体——
-
研究领域——
-
适应症——
化学信息
-
CAS Number90162-60-0
-
分子量236.275
-
分子式C11H16N4O2
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESCC(C)Cn1cnc2n(C)c(=O)n(C)c(=O)c12
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Morikawa T, et al. Ellagic acid glycosides with hepatoprotective activity from traditional Tibetan medicine Potentilla anserina. J Nat Med. 2018 Jan;72(1):317-325.
产品手册




关联产品
-
Eledoisin Related Pe...
Eledoisin相关肽(2TFA)是速激肽受体配体。P物质和eledoisin相关肽对呼吸神经元和反射性中间神经元有兴奋作用,但与谷氨酸诱导的作用相比,兴奋起效较慢,放电后持续时间较长。
-
PF-4840154
PF-4840154 是大鼠和人 TrpA1 通道的有效选择性激动剂,可在小鼠中引发 TrpA1 介导的伤害行为,rTrpA1 和 hTrpA1 的 EC50 分别为 97 nM 和 23 nM。
-
Jacobine
Jacobine induces significant dose-dependent DNA-DNA interstrand cross-linking over the entire range of doses.