Ipsapirone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

5-HT1A受体激动剂。

5-HT1A receptor agonist(In Vivo):Ipsapirone (2.5-80 mg/kg) induces a mild hind limb abduction and a slight flattening of body posture at the highest dose. Ipsapirone (35 mg/kg; i.p.) decreases the body temperature in rats and mice.

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Ipsapirone inhibits induced by 8-OH-DPAT and 5-methoxydimethyltryptamine (agonists of 5-HT1A receptors) behavioural effects (flat body posture and forepaw treading) in normal and reserpinized rats.Ipsapirone (2.5-80 mg/kg), given alone to rats induces a slight flattening of body posture (~ 1 point at the highest dose) and a mild hind limb abduction observed at doses 2.5-80 mg/kg. Ipsapirone given alone at low doses (2.5-10 mg/kg i.p.) does not significantly change the body temperature in rats and mice, but decreased it in both those species at high doses (35 mg/kg i.p.) by ca. 2-2.5℃. Animal Model:Male Albino-Swiss mice (18-24 g) and male Wistar rats (160-200 g).Dosage:5 and 10 mg/kg.Administration:IP 30 min before 8-OH-DPAT and 5-MeODMT injections.Result:Behavioural responses (flat body posture, forepaw treading) to 8-OH-DPAT (5 mg/kg s.c.) in rats were antagonized by Ipsapirone (5 and 10 mg/kg i.p.).

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Others

Other Targets

Fungal

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95847-70-4

401.49

C19H23N5O3S

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (62.27 mM)

O=C1N(CCCCN2CCN(CC2)c2ncccn2)S(=O)(=O)c2ccccc12

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(-20℃)

With Ice Pack

≥ 2 years