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Ibodutant
CAS No. 522664-63-7
Ibodutant ( MEN-15596;MEN 15596 )
产品货号. M14847 CAS No. 522664-63-7
A potent and selective linear tachykinin NK2 receptor antagonist with pKb of 9.3; displays >1,000-fold selectivity over NK1 and NK3 (pKb<6).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥7857 | 有现货 |
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| 50MG | ￥16038 | 有现货 |
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| 100MG | ￥20250 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Ibodutant
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent and selective linear tachykinin NK2 receptor antagonist with pKb of 9.3; displays >1,000-fold selectivity over NK1 and NK3 (pKb<6).
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产品描述A potent and selective linear tachykinin NK2 receptor antagonist with pKb of 9.3; displays >1,000-fold selectivity over NK1 and NK3 (pKb<6); induces a concentration-dependent rightward shift of the [βAla(8)]NKA(4-10) concentration-response curves without depressing the maximal contractile effect (3-100 nM); shows good in vivo activity after intravenous, intraduodenal, and oral administration in guinea pigs.Irritable Bowel Syndrome Phase 3 Clinical
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同义词MEN-15596;MEN 15596
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通路GPCR/G Protein
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靶点Neurokinin Receptor
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受体Neurokinin Receptor
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研究领域Other Indications
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适应症Irritable Bowel Syndrome
化学信息
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CAS Number522664-63-7
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分子量644.87
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分子式C37H48N4O4S
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(C1=CC2=CC=C(C)C=C2S1)NC3(C(N[C@H](CC4=CC=CC=C4)C(NCC5CCN(CC6CCOCC6)CC5)=O)=O)CCCC3
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化学全称6-methyl-N-(1-(((R)-1-oxo-3-phenyl-1-(((1-((tetrahydro-2H-pyran-4-yl)methyl)piperidin-4-yl)methyl)amino)propan-2-yl)carbamoyl)cyclopentyl)-2,3-dihydrobenzo[b]thiophene-2-carboxamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Meini S, et al. J Pharmacol Exp Ther. 2009 May;329(2):486-95.
2. Fedi V, et al. J Med Chem. 2007 Oct 4;50(20):4793-807.
3. Santicioli P, et al. Eur J Pharmacol. 2013 Feb 28;702(1-3):32-7.
2. Fedi V, et al. J Med Chem. 2007 Oct 4;50(20):4793-807.
3. Santicioli P, et al. Eur J Pharmacol. 2013 Feb 28;702(1-3):32-7.
产品手册
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