Ibiglustat ( Venglustat;Genz-682452;GZ452 )

产品货号. M11673 CAS No. 1401090-53-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Ibiglustat
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

An orally active, selective and potent Glucosylceramide synthase (GCS) inhibitor with central nervous system (CNS) access.
产品描述

An orally active, selective and potent Glucosylceramide synthase (GCS) inhibitor with central nervous system (CNS) access; exhibits significantly lower tissue levels of GL-3 and lyso-GL-3 and a delayed progression of a thermal nociceptive response in administered Fabry mice; shows favorable pharmacological properties and safety profile.Other Indication Phase 2 Clinical
同义词

Venglustat;Genz-682452;GZ452
通路

Others
靶点

Other Targets
受体

glucosylceramide synthase
研究领域

Other Indications
适应症

Other Disease

CAS Number

1401090-53-6
分子量

389.49
分子式

C20H24FN3O2S
纯度

>98% (HPLC)
溶解度

DMSO: 10 mM （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

O=C(O[C@@H]1CN2CCC1CC2)NC(C)(C3=CSC(C4=CC=C(F)C=C4)=N3)C
化学全称

(3S)-1-azabicyclo[2.2.2]octan-3-yl N-{2-[2-(4-fluorophenyl)- 1,3-thiazol-4-yl]propan-2-yl}carbamate

1. Ashe KM, et al. Mol Med. 2015 Apr 30;21:389-99.
2. Marshall J, et al. Mol Ther. 2016 Jun;24(6):1019-1029.

计算器

产品手册

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