IWP-L6 ( IWP-L6;PORCN Inhibitor III )

产品货号. M17292 CAS No. 1427782-89-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

IWP-L6
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

IWP-L6 is an extremely effective Porcn inhibitor (EC50: 0.5 nM).
产品描述

IWP-L6, also known as PORCN Inhibitor III and Wnt Pathway Inhibitor XIX, is a potent inhibitor of PORCN (EC50 = 0.5 nM). Porcupine is a member of the membrane-bound O-acyltransferase family of proteins. It catalyzes the palmitoylation of Wnt proteins, a process required for their secretion and activity.
同义词

IWP-L6;PORCN Inhibitor III
通路

Others
靶点

Other Targets
受体

Porcn
研究领域

Cancer
适应症

——

CAS Number

1427782-89-5
分子量

472.58
分子式

C25H20N4O2S2
纯度

98%
溶解度

DMSO : 1.43 mg/mL 3.03 mM;
SMILES

O=C(CSc1nc2c(SCC2)c(=O)n1c1ccccc1)Nc1ncc(cc1)c1ccccc1
化学全称

N-(5-phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide

1. Wang X, et al. J Med Chem. 2013, 56(6), 2700-2704.

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