ISO-1 ( ISO-1; ISO 1; ISO1; MIF Antagonist )

产品货号. M17520 CAS No. 478336-92-4

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

ISO-1
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

ISO-1 is an inhibitor of the dopachrome tautomerase activity, blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages.
产品描述

ISO-1, also known as MIF Antagonist and ISO-1 and Macrophage Migration Inhibitory Factor, is a MIF inhibitor. ISO-1 has CAS#478336-92-4. MDK-6924 Protects Photoreceptors and Reduces Gliosis in Experimental Retinal Detachment. Systemic administration of the MIF inhibitor ISO-1 significantly blocked photoreceptor apoptosis, outer nuclear layer (ONL) thinning, and retinal gliosis. ISO-1 and MIF knockout (MIFKO) had greater accumulation of Müller glia pERK expression in the detached retina, suggesting that Müller survival pathways might underlie the neuroprotective response.
同义词

ISO-1; ISO 1; ISO1; MIF Antagonist
通路

Others
靶点

Other Targets
受体

MIF
研究领域

Inflammation/Immunology
适应症

——

1. Xu L, et al. Drug Discov Today. 2013 Jun;18(11-12):592-600.

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