ISO-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ISO-1 is an inhibitor of the dopachrome tautomerase activity, blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages.

ISO-1, also known as MIF Antagonist and ISO-1 and Macrophage Migration Inhibitory Factor, is a MIF inhibitor. ISO-1 has CAS#478336-92-4. MDK-6924 Protects Photoreceptors and Reduces Gliosis in Experimental Retinal Detachment. Systemic administration of the MIF inhibitor ISO-1 significantly blocked photoreceptor apoptosis, outer nuclear layer (ONL) thinning, and retinal gliosis. ISO-1 and MIF knockout (MIFKO) had greater accumulation of Müller glia pERK expression in the detached retina, suggesting that Müller survival pathways might underlie the neuroprotective response.

ISO-1; ISO 1; ISO1; MIF Antagonist

Others

Other Targets

MIF

Inflammation/Immunology

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478336-92-4

235.2

C12H13NO4

98%

DMSO : ≥ 36 mg/mL; 153.04 mM

COC(=O)CC1CC(=NO1)c1ccc(O)cc1

4,5-dihydro-3-(4-hydroxyphenyl)-5-isoxazoleacetic acid, methyl ester

(-20℃)

With Ice Pack

≥ 2 years