
ISA-2011B
CAS No. 1395347-24-6
ISA-2011B ( —— )
产品货号. M26721 CAS No. 1395347-24-6
ISA-2011B 是 PIP5K1α 的抑制剂,可用于抗癌研究。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥2341 | 有现货 |
![]() ![]() |
10MG | ¥3742 | 有现货 |
![]() ![]() |
25MG | ¥6423 | 有现货 |
![]() ![]() |
50MG | ¥9153 | 有现货 |
![]() ![]() |
100MG | ¥12312 | 有现货 |
![]() ![]() |
200MG | 获取报价 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称ISA-2011B
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述ISA-2011B 是 PIP5K1α 的抑制剂,可用于抗癌研究。
-
产品描述ISA-2011B is an inhibitor of PIP5K1α and can be used in anticancer studies.(In Vitro):ISA-2011B treatment abolished AR expression in the nucleus, without depleting the cytoplasmic AR . The proliferation rate of PC-3 cells after treatment with ISA-2011B at 10, 20, and 50 μM is obviously reduced to 58.77%, 48.65%, and 21.62% of vehicle-treated controls, respectively. ISA-2011B leads to a remarkable reduction in AR-V7 and CDK1 in both nucleus and cytoplasm of 22Rv1 cells. ISA-2011B shows the highest binding affinity to PIP5K1α, and to MAP/microtubule affinity-regulating kinase 1 and 4 (MARK1 and MARK4) across 460 kinases. ISA-2011B treatment inhibits PIP5K1α expression by 78.6% in PC-3 cells .(In Vivo):In xenograft mice, ISA-2011B disrupts protein stabilization of AR-V7 which is dependent on PIP5K1α, leading to suppression of invasive growth of AR-V7-high tumors. Overexpression of AR-V7 increases PIP5K1α, promotes rapid growth of PCa in xenograft mice, whereas inhibition of PIP5K1α by its inhibitor ISA-2011B suppresses the growth and invasiveness of xenograft tumors overexpressing AR-V7. ISA-2011B obviously suppresses the growth of tumor cells in xenograft mice and is mediated by targeting PIP5K1α-associated PI3K/AKT and the downstream survival, proliferation, and invasion pathways .
-
体外实验The proliferation rate of PC-3 cells after treatment with ISA-2011B at 10, 20, and 50 μM is significantly reduced to 58.77%, 48.65%, and 21.62% of vehicle-treated controls, respectively. ISA-2011B exhibits the highest binding affinity to PIP5K1α, and to MAP/microtubule affinity-regulating kinase 1 and 4 (MARK1 and MARK4) across 460 kinases. ISA-2011B treatment inhibits PIP5K1α expression by 78.6% in PC-3 cells. ISA-2011B leads to a remarkable reduction in AR-V7 and CDK1 in both nucleus and cytoplasm of 22Rv1 cells. ISA-2011B treatment also abolishes AR expression in the nucleus, without depleting the cytoplasmic AR.
-
体内实验ISA-2011B significantly inhibits growth of tumor cells in xenograft mice, and is mediated by targeting PIP5K1α-associated PI3K/AKT and the downstream survival, proliferation, and invasion pathways. Overexpression of AR-V7 increases PIP5K1α, promotes rapid growth of PCa in xenograft mice, whereas inhibition of PIP5K1α by its inhibitor ISA-2011B suppresses the growth and invasiveness of xenograft tumors overexpressing AR-V7. ISA-2011B disrupts protein stabilization of AR-V7 which is dependent on PIP5K1α, leading to suppression of invasive growth of AR-V7-high tumors in xenograft mice.
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体estrogen receptor
-
研究领域——
-
适应症——
化学信息
-
CAS Number1395347-24-6
-
分子量423.85
-
分子式C22H18ClN3O4
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 100 mg/mL (235.93 mM)
-
SMILES[H][C@@]12Cc3cc4OCOc4cc3[C@H](N1C(=O)CN(C)C2=O)c1c[nH]c2ccc(Cl)cc12
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1..Tatay E, et al. Estrogenic activity of zearalenone, α-zearalenol and β-zearalenol assessed using the E-screen assay in MCF-7 cells. Toxicol Mech Methods. 2018 May;28(4):239-242.
产品手册




关联产品
-
Glucotropaeolin pota...
Glucotropaeolin 钾存在于十字花科蔬菜中,可适度减少动物的自发 DNA 损伤。
-
Sudan II
苏丹II是一种染料。
-
D-Glucose 6-phosphat...
在细胞中,当葡萄糖被己糖激酶或葡萄糖激酶磷酸化或在糖原分解过程中被磷酸葡萄糖变位酶转化为葡萄糖-1-磷酸时,会产生 D-葡萄糖 6-磷酸 (G6P)。 G6P 位于糖酵解和磷酸戊糖途径的起点。当血糖水平高时,它也可以作为糖原储存。