IRG1-IN-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

IRG1-IN-1 是衣康酸衍生物。IRG1-IN-1 可以抑制免疫反应基因 1 (IRG1) 的活性。IRG1-IN-1 可用于癌症、炎症和自身免疫性疾病的研究。

IRG1-IN-1 is an itaconic acid derivative. IRG1-IN-1 can inhibit immune-responsive gene 1 (IRG1) activity. IRG1-IN-1 can be used for the research of cancer, inflammation and autoimmune diseases.

IRG1-IN-1(compound 6) (0.5 mM; 2 mM) reduces production of itaconic acid and the secretion of TNFα from LPS-stimulated human monocyte derived macrophages (hMDMs) .IRG1-IN-1 (0.5 mM; 1 mM) inhibits the proliferation of C-IRG1-9 rat glioma cells.IRG1-IN-1(10 nM) increases proliferation of TCR-activated hCD8+ T cells.IRG1-IN-1(10μM) shows depletion of trimethylation of histone 3 at lysine 4 (H3K4me3) in CR-activated hCD8+ T cells.Western Blot Analysis Cell Line:TCR-activated hCD8+ T cells Concentration:10 μM Incubation Time:24-72 h Result:Decreased protein levels of histone 3 (H3).Cell Proliferation Assay Cell Line:C-IRG1-9 rat glioma cells and TCR-activated hCD8+ T cells Concentration:0.5 mM; 1 mM; 10 nM Incubation Time:48-96 h Result:Inhibited the proliferation of C-IRG1-9 rat glioma cells and increased proliferation of TCR-activated hCD8+ T cells.

IRG1-IN-1 (compound 6) (i.p.; 0.2 mg/kg; 27 days) shows antitumor effect in C57BL/6 mice.Animal Model:C57BL/6 mice Dosage:0.2 mg/kg Administration:IP; 27 days Result:Increased survival of C57BL/6 mice bearing mouse CT26 colorectal tumors.Decreased intratumoral frequency of M-MDSCs in tumors.

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Others

Other Targets

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2407652-42-8

314.31

C18H15FO4

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (318.16 mM; 超声助溶 )

O=C(O)C(=CC1=CC=C(F)C=C1)C(C(=O)O)CC=2C=CC=CC2

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(-20℃)

With Ice Pack

≥ 2 years