021-51111890
购物车（0）
sales@molnova.cn
IPI-3063
CAS No. 1425043-73-7
IPI-3063 ( —— )
产品货号. M23579 CAS No. 1425043-73-7
IPI-3063 是一种有效的选择性 PI3K p110δ 抑制剂 (IC50: 2.5 ± 1.2 nM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥786 | 有现货 |
|
| 5MG | ￥1442 | 有现货 |
|
| 10MG | ￥2406 | 有现货 |
|
| 25MG | ￥4836 | 有现货 |
|
| 50MG | ￥6877 | 有现货 |
|
| 100MG | ￥9153 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称IPI-3063
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述IPI-3063 是一种有效的选择性 PI3K p110δ 抑制剂 (IC50: 2.5 ± 1.2 nM)。
-
产品描述IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5?±?1.2 nM).
-
体外实验IPI-3063 inhibits p110α, p110β, and p110γ with IC50s of 1171±533 nM, 1508±624 nM, and 2187±1529 nM, respectively. IPI-3063 potently reduces mouse B cell proliferation, survival, and plasmablast differentiation while increasing antibody class switching to IgG1. IPI-3063 is a p110δ selective compound with an IC50=0.1?nM in p110δ-specific cell-based assays and cellular IC50 values for the other class I PI3K isoforms are at least 1,000-fold higher (IC50=1901±1318 nM for p110α, IC50=102.8±35.7 nM for p110β, IC50=418.8±117.2 nM for p110γ). IPI-3063 is very potent in reducing p-AKT (significant effect at 1?nM). IPI-3063 also reduces p-ERK1/2 with a significant effect at 10?nM. IPI-3063 is very potent, achieving a significant decrease in B cell survival when present at 10?nM.
-
体内实验——
-
同义词——
-
通路PI3K/Akt/mTOR signaling
-
靶点PI3K
-
受体p110α|p110β|p110γ|p110δ
-
研究领域——
-
适应症——
化学信息
-
CAS Number1425043-73-7
-
分子量455.51
-
分子式C25H25N7O2
-
纯度>98% (HPLC)
-
溶解度DMSO:83.33 mg/mL (182.94 mM)
-
SMILESC[C@@H](C1=CC2=C(C(=CC=C2)C3=CN(C(=O)C=C3)C)C(=O)N1C(C)C)NC4=NC=NC(=C4C#N)N
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Chiu H, et al. The Selective Phosphoinoside-3-Kinase p110δ Inhibitor IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and Differentiation. Front Immunol. 2017 Jun 30;8:747.
