IPA-3
CAS No. 42521-82-4
IPA-3 ( IPA-3; IPA 3; IPA3 )
产品货号. M18540 CAS No. 42521-82-4
IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6).
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥316 | 有现货 |
|
10MG | ¥494 | 有现货 |
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25MG | ¥956 | 有现货 |
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50MG | ¥1742 | 有现货 |
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100MG | ¥3070 | 有现货 |
|
200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称IPA-3
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6).
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产品描述IPA-3 is a potent and selective PAK1 inhibitor. IPA-3 inhibits the growth of liver cancer cells by suppressing PAK1 and NF-κB activation. IPA-3 treatment significantly inhibited the growth of HCC cells. The mechanisms through which IPA-3 treatment suppresses HCC cell growth are enhancement of apoptosis and blockage of activation of NF-κB. IPA-3 not only inhibits the HCC cell growth, but also suppresses the metastatic potential of HCC cells. Nude mouse xenograft assay demonstrated that IPA-3 treatment significantly reduced the tumor growth rate and decreased tumor volume, indicating that IPA-3 can suppress the in vivo tumor growth of HCC cells. Hepatocellular carcinoma (HCC) is one of the major malignancies worldwide and is associated with poor prognosis due to the high incidences of metastasis and tumor recurrence. Overexpression of p21-activated protein kinase 1 (PAK1) is frequently observed in HCC and is associated with a more aggressive tumor behavior, suggesting that PAK1 is a potential therapeutic target in HCC.
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同义词IPA-3; IPA 3; IPA3
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通路Others
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靶点Other Targets
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受体PAK1
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研究领域Cancer
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适应症——
化学信息
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CAS Number42521-82-4
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分子量350.45
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分子式C20H14O2S2
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纯度98%
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溶解度DMSO : ≥ 100 mg/mL 285.35 mM; H2O : < 0.1 mg/mL
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SMILESOC1=CC=C2C=CC=CC2=C1SSC1=C2C=CC=CC2=CC=C1O
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化学全称1,1'-disulfanediylbis(naphthalen-2-ol)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Deacon SW, et al. Chem Biol, 2008, 15(4), 322-331.
产品手册
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