IMT1B ( 3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-; LDC203974 )

产品货号. M24045 CAS No. 2304621-06-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

IMT1B
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

IMT1B is an orally active, noncompetitive and specific allosteric inhibitor of mitochondrial RNA polymerase (POLRMT) and inhibits mitochondrial DNA (mtDNA) expression. It has anti-tumour effects.
产品描述

IMT1B is an orally active, noncompetitive and specific allosteric inhibitor of mitochondrial RNA polymerase (POLRMT) and inhibits mitochondrial DNA (mtDNA) expression. It has anti-tumour effects.
同义词

3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-; LDC203974
通路

Others
靶点

Other Targets
受体

POLRMT
研究领域

——
适应症

——

CAS Number

2304621-06-3
分子量

473.9
分子式

C24H21ClFNO6
纯度

>98% (HPLC)
溶解度

DMSO:250 mg/mL?(527.56 mM;?Need ultrasonic)
SMILES

C[C@H](C(=O)N1CCC[C@@H](C1)C(=O)O)OC2=CC3=C(C=C2)C(=CC(=O)O3)C4=C(C=C(C=C4)F)Cl
化学全称

——

1.Nina A Bonekamp, et al. Small-molecule inhibitors of human mitochondrial DNA transcription. Nature. 2020 Dec;588(7839):712-716.

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产品手册

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