IMR-1 ( IMR-1 | IMR 1 | IMR1. Inhibitor of Mastermind Recruitment-1 )

产品货号. M17472 CAS No. 310456-65-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

IMR-1
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

IMR-1是一类新型Notch抑制剂，针对转录激活，IC50为6 μMol/L。
产品描述

IMR-1 is a Mastermind Recruitment inhibitor. IMR-1 disrupted the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex on chromatin, thereby attenuating Notch target gene transcription. IMR-1 inhibited the growth of Notch-dependent cell lines and significantly abrogated the growth of patient-derived tumor xenografts.
体外实验

——
体内实验

Animal Model:Nude mouses with adenocarcinoma xenograft.Dosage:15mg/kg Administration:I.p.; for 28 days Result:Blocks tumor establishment.
同义词

IMR-1 | IMR 1 | IMR1. Inhibitor of Mastermind Recruitment-1
通路

Others
靶点

Other Targets
受体

Notch
研究领域

Cancer
适应症

——

CAS Number

310456-65-6
分子量

353.41
分子式

C15H15NO5S2
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 100 mg/mL 282.96 mM; H2O : < 0.1 mg/mL
SMILES

C(=O)(COc1c(cc(cc1)/C=C/1\SC(=S)NC1=O)OC)OCC
化学全称

(E)-Ethyl 2-(2-methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetate

1.Astudillo L, et al. Cancer Res. 2016, 76(12):3593-603.

计算器

产品手册

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