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IMM-H007
CAS No. 1221412-23-2
IMM-H007 ( —— )
产品货号. M23389 CAS No. 1221412-23-2
IMM-H007 是一种新型降脂剂，可增加 abca1 蛋白的表达。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1531 | 有现货 |
|
| 10MG | ￥2398 | 有现货 |
|
| 25MG | ￥4795 | 有现货 |
|
| 50MG | ￥6845 | 有现货 |
|
| 100MG | ￥9477 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称IMM-H007
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述IMM-H007 是一种新型降脂剂，可增加 abca1 蛋白的表达。
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产品描述IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression.
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体外实验——
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体内实验IMM-H007 inhibits fatty acid import into hepatocytes and liver lipogenesis, and concomitantly stimulates fatty acid oxidation, autophagy, and export of hepatic lipids.IMM-H007 (200?mg/kg, Orally, once per day for 10 days) inhibits ISO-induced cardiac fibrosis and diastolic dysfunction independently of AMPKα2 expression, reduces ISO-induced Smad2/3 phosphorylation downstream of TGFβ1 and cardiac fibrosis via an AMPKα2-independent pathway, but the inhibition of TGFβ1 expression is AMPKα2-dependent.
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number1221412-23-2
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分子量369.4
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分子式C18H19N5O4
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纯度>98% (HPLC)
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溶解度DMSO:10 mM
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SMILESCC(=O)OC[C@H]1CC[C@@H](O1)N2C=NC3=C(N=CN=C32)NC4=CC(=CC=C4)O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Jy C , MD Hong, Hyl F , et al. IMM-H007, a novel small molecule inhibitor for atherosclerosis, represses endothelium inflammation by regulating the activity of NF-κB and JNK/AP1 signaling[J]. Toxicology and Applied Pharmacology, 2019, 381:114732-.
产品手册
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