IMM-01 ( —— )

产品货号. M27816 CAS No. 218795-74-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

IMM-01
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

IMM-01 is a novel class of small-molecule agonists of the mammalian Diaphanous (mDia)-related formins, which act downstream of Rho GTPases to assemble actin filaments, and their organization with microfilaments to establish and maintain cell polarity during migration and asymmetric division.
产品描述

IMM-01 is a novel class of small-molecule agonists of the mammalian Diaphanous (mDia)-related formins, which act downstream of Rho GTPases to assemble actin filaments, and their organization with microfilaments to establish and maintain cell polarity during migration and asymmetric division. GTP-bound Rho activates mDia family members by disrupting the interaction between the DID and DAD autoregulatory domains, which releases the FH2 domain to modulate actin and microtubule dynamics.
同义词

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通路

Others
靶点

Other Targets
受体

CYP3A4;Calcium Channel;P-gp
研究领域

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适应症

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1.Kubo Y, et al. Blood-to-Retina Transport of Fluorescence-Labeled Verapamil at the Blood-Retinal Barrier. Pharm Res. 2018 Mar 12;35(5):93.

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