IITZ-01 ( Autophagy inhibitor IITZ-01 )

产品货号. M12762 CAS No. 1807988-47-1

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

IITZ-01
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

IITZ-01 (Autophagy inhibitor IITZ-01) is a novel potent lysosomotropic autophagy inhibitor.
产品描述

IITZ-01 (Autophagy inhibitor IITZ-01) is a novel potent lysosomotropic autophagy inhibitor, exhibits >10-fold potent autophagy inhibition along with 12- to 20-fold better cytotoxic action than Chloroquine; enhances autophagosome accumulation but inhibit autophagosomal degradation by impairing lysosomal function, finally resulting in the inhibition of autophagy, also abolishes mitochondrial membrane potential and triggers apoptosis through the mitochondria-mediated pathway (TNBC cells IC50=1.54 uM, 48 h); displays potent antitumor action in vivo through autophagy inhibition and apoptosis induction in MDA-MB-231 breast cancer xenograft model.
同义词

Autophagy inhibitor IITZ-01
通路

Autophagy
靶点

Autophagy
受体

Autophagy
研究领域

——
适应症

——

CAS Number

1807988-47-1
分子量

482.52
分子式

C26H23FN8O
纯度

>98% (HPLC)
溶解度

DMSO : 150 mg/mL 310.87 mM; H2O : < 0.1 mg/mL
SMILES

FC1=CC=C(NC2=NC(N3CCOCC3)=NC(NC4=CC=C(C5=NC6=CC=CC=C6N5)C=C4)=N2)C=C1
化学全称

N2-(4-(1H-benzo[d]imidazol-2-yl)phenyl)-N4-(4-fluorophenyl)-6-morpholino-1,3,5-triazine-2,4-diamine

1. Guntuku L, et al. Oncogene. 2018 Aug 30. doi: 10.1038/s41388-018-0446-2.

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