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IITZ-01
CAS No. 1807988-47-1
IITZ-01 ( Autophagy inhibitor IITZ-01 )
产品货号. M12762 CAS No. 1807988-47-1
IITZ-01（自噬抑制剂 IITZ-01）是一种新型强效溶酶体自噬抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥267 | 有现货 |
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| 5MG | ￥446 | 有现货 |
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| 10MG | ￥786 | 有现货 |
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| 25MG | ￥1596 | 有现货 |
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| 50MG | ￥2811 | 有现货 |
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| 100MG | ￥4350 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称IITZ-01
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述IITZ-01（自噬抑制剂 IITZ-01）是一种新型强效溶酶体自噬抑制剂。
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产品描述IITZ-01 (Autophagy inhibitor IITZ-01) is a novel potent lysosomotropic autophagy inhibitor, exhibits >10-fold potent autophagy inhibition along with 12- to 20-fold better cytotoxic action than Chloroquine; enhances autophagosome accumulation but inhibit autophagosomal degradation by impairing lysosomal function, finally resulting in the inhibition of autophagy, also abolishes mitochondrial membrane potential and triggers apoptosis through the mitochondria-mediated pathway (TNBC cells IC50=1.54 uM, 48 h); displays potent antitumor action in vivo through autophagy inhibition and apoptosis induction in MDA-MB-231 breast cancer xenograft model.
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体外实验IITZ-01 (0-2 μM, 24 h) enhances autophagosomes formation as indicated by increased expression of LC3-II levels time- and dose-dependently intriple-negative breast cancer (TNBC) cell lines (MDA-MB-231 and MDA-MB-453). IITZ-01 also demonstrates potent autophagy inhibitory activity in other breast, lung, and colon cancer cells.Western Blot Analysis Cell Line:Triple-negative breast cancer (TNBC) cell lines (MDA-MB-231 and MDA-MB-453).Concentration:0-2 μM.Incubation Time:24 hours.Result:Enhanced autophagosomes formation as indicated by increased expression of LC3-II levels.
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体内实验IITZ-01 (45 mg/kg, i.p. every alternate day for 4 weeks) inhibits average breast tumor growth when compared with control from third day of treatment in triple-negative breast tumor models in mice. Animal Model:MDA-MB-231 (TNBC)/green fluorescent protein (GFP) orthotropic breast cancer xenografts were developed in CrTac:NCr-Foxnnu BALB/c female nude mice.Dosage:45 mg/kg.Administration:Intraperitoneal every alternate day for 4 weeks.Result:Inhibited average breast tumor growth when compared with control from third day of treatment.
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同义词Autophagy inhibitor IITZ-01
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通路Autophagy
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靶点Autophagy
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受体Autophagy
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研究领域——
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适应症——
化学信息
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CAS Number1807988-47-1
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分子量482.523
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分子式C26H23FN8O
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纯度>98% (HPLC)
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溶解度DMSO : 150 mg/mL 310.87 mM; H2O : < 0.1 mg/mL
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SMILESFC1=CC=C(NC2=NC(N3CCOCC3)=NC(NC4=CC=C(C5=NC6=CC=CC=C6N5)C=C4)=N2)C=C1
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化学全称N2-(4-(1H-benzo[d]imidazol-2-yl)phenyl)-N4-(4-fluorophenyl)-6-morpholino-1,3,5-triazine-2,4-diamine
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Guntuku L, et al. Oncogene. 2018 Aug 30. doi: 10.1038/s41388-018-0446-2.
产品手册
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