
ICCB280
CAS No. 2041072-41-5
ICCB280 ( —— )
产品货号. M23912 CAS No. 2041072-41-5
ICCB280 能够诱导 ATRA 耐药患者原始细胞的分化和凋亡,这强烈表明该化合物的活性可以克服对目前预后不良的 AML 的其他疗法的耐药性。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥875 | 有现货 |
![]() ![]() |
5MG | ¥1442 | 有现货 |
![]() ![]() |
10MG | ¥2608 | 有现货 |
![]() ![]() |
25MG | ¥4228 | 有现货 |
![]() ![]() |
50MG | ¥6148 | 有现货 |
![]() ![]() |
100MG | ¥8586 | 有现货 |
![]() ![]() |
500MG | ¥17253 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称ICCB280
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述ICCB280 能够诱导 ATRA 耐药患者原始细胞的分化和凋亡,这强烈表明该化合物的活性可以克服对目前预后不良的 AML 的其他疗法的耐药性。
-
产品描述ICCB280 was capable of inducing differentiation and apoptosis of ATRA-resistant patient blasts strongly signify that the activity of this compound can overcome resistance to other current therapies for AML with an unfavorable prognosis.
-
体外实验ICCB280 (0.1-50 μM; 48 h) suppresses the HL-60 cell growth, with an IC50 of 8.6 μM.ICCB280 (10 μM; 2-8 d) increases the C/EBPα expression (mRNA and protein) and modulates its target genes in HL-60 cells.ICCB280 (10 μM; 7 d) induces granulocytic differentiation and subsequent apoptosis in HL-60 cells. Cell Viability Assay Cell Line:HL-60 cells Concentration:0.1, 0.5, 1, 5, 10, 50 μM Incubation Time:48 hours Result:Induced cell growth arrest, with an IC50 of 8.6 μM.Western Blot Analysis Cell Line:HL-60 cells Concentration:10 μM Incubation Time:2, 4, 6, 8 days Result:Upregulated the C/EBPα protein on day 4.
-
体内实验——
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体C/EBPα
-
研究领域——
-
适应症——
化学信息
-
CAS Number2041072-41-5
-
分子量386.4
-
分子式C23H18N2O4
-
纯度>98% (HPLC)
-
溶解度DMSO:85mg/mL (219.98mM)
-
SMILESO=C1N(C2=CC=CC=C2OC)C(/C=C/C3=CC=C(O)C(O)=C3)=NC4=C1C=CC=C4
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Radomska HS, Jernigan F, Nakayama S, et al. A Cell-Based High-Throughput Screening for Inducers of Myeloid Differentiation. J Biomol Screen. 2015;20(9):1150-1159. doi:10.1177/1087057115592220
产品手册




关联产品
-
Kojic acid
曲酸是一种真菌代谢物,可抑制酪氨酸酶(一种参与黑色素合成的酶),对蘑菇酪氨酸酶的 IC50 值为 30.6 μM。
-
17-Diaminoheptane
1,7-二氨基庚烷是一种化合物。
-
Nemifitide diTFA
Nemifitide (diTFA) is is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. Nemifitide (diTFA) is a peptide analog of melanocyte-inhibiting factor (MIF).