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ICCB280
CAS No. 2041072-41-5
ICCB280 ( —— )
产品货号. M23912 CAS No. 2041072-41-5
ICCB280 能够诱导 ATRA 耐药患者原始细胞的分化和凋亡，这强烈表明该化合物的活性可以克服对目前预后不良的 AML 的其他疗法的耐药性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥875 | 有现货 |
|
| 5MG | ￥1442 | 有现货 |
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| 10MG | ￥2608 | 有现货 |
|
| 25MG | ￥4228 | 有现货 |
|
| 50MG | ￥6148 | 有现货 |
|
| 100MG | ￥8586 | 有现货 |
|
| 500MG | ￥17253 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称ICCB280
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述ICCB280 能够诱导 ATRA 耐药患者原始细胞的分化和凋亡，这强烈表明该化合物的活性可以克服对目前预后不良的 AML 的其他疗法的耐药性。
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产品描述ICCB280 was capable of inducing differentiation and apoptosis of ATRA-resistant patient blasts strongly signify that the activity of this compound can overcome resistance to other current therapies for AML with an unfavorable prognosis.
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体外实验ICCB280 (0.1-50 μM; 48 h) suppresses the HL-60 cell growth, with an IC50 of 8.6 μM.ICCB280 (10 μM; 2-8 d) increases the C/EBPα expression (mRNA and protein) and modulates its target genes in HL-60 cells.ICCB280 (10 μM; 7 d) induces granulocytic differentiation and subsequent apoptosis in HL-60 cells. Cell Viability Assay Cell Line:HL-60 cells Concentration:0.1, 0.5, 1, 5, 10, 50 μM Incubation Time:48 hours Result:Induced cell growth arrest, with an IC50 of 8.6 μM.Western Blot Analysis Cell Line:HL-60 cells Concentration:10 μM Incubation Time:2, 4, 6, 8 days Result:Upregulated the C/EBPα protein on day 4.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体C/EBPα
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研究领域——
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适应症——
化学信息
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CAS Number2041072-41-5
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分子量386.4
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分子式C23H18N2O4
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纯度>98% (HPLC)
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溶解度DMSO:85mg/mL (219.98mM)
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SMILESO=C1N(C2=CC=CC=C2OC)C(/C=C/C3=CC=C(O)C(O)=C3)=NC4=C1C=CC=C4
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Radomska HS, Jernigan F, Nakayama S, et al. A Cell-Based High-Throughput Screening for Inducers of Myeloid Differentiation. J Biomol Screen. 2015;20(9):1150-1159. doi:10.1177/1087057115592220
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