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ICA-27243
CAS No. 325457-89-4
ICA-27243 ( —— )
产品货号. M22578 CAS No. 325457-89-4
ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 is a potent and orally active KCNQ2/Q3 potassium channel opener (EC50: 0.38 μM).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥583 | 有现货 |
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| 10MG | ￥988 | 有现货 |
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| 25MG | ￥1879 | 有现货 |
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| 50MG | ￥3102 | 有现货 |
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| 100MG | ￥4528 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称ICA-27243
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 is a potent and orally active KCNQ2/Q3 potassium channel opener (EC50: 0.38 μM).
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产品描述ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 is a potent and orally active KCNQ2/Q3 potassium channel opener (EC50: 0.38 μM). ICA-27243 also has antiepileptic and anticonvulsant effects. ICA-27243 increases both 86Rb+ efflux (EC50 = 0.2 μM) and whole-cell currents in Chinese hamster ovary cells stably expressing heteromultimeric KCNQ2/Q3 channels (EC50 = 0.4 μM). ICA-27243 produces membrane potential hyperpolarization that could be prevented by coadministration with the M-current inhibitors XE-991 and Linopirdine, in SH-SY5Y human neuroblastoma cells .In the mouse maximal electroshock epilepsy model, ICA-27243 (1-100 mg/kg; oral administration; male CD-1 mice) has anticonvulsant activity (ED50: 8.4 mg/kg).
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同义词——
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通路Cell Cycle/DNA Damage
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靶点Potassium Channel
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受体KCNQ2/Q3 potassium channel
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研究领域——
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适应症——
化学信息
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CAS Number325457-89-4
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分子量268.65
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分子式C12H7ClF2N2O
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纯度>98% (HPLC)
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溶解度DMSO:247 mg/mL (919.41mM; Need ultrasonic)
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SMILESFc1ccc(cc1F)C(=O)Nc1ccc(Cl)nc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Wickenden AD, et al. N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. Mol Pharmacol. 2008 Mar;73(3):977-86.
产品手册
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