
Hydroxyquinoline
CAS No. 148-24-3
Hydroxyquinoline ( Oxyquinoline | NSC 2039 | NSC-2039 | NSC2039 )
产品货号. M12044 CAS No. 148-24-3
8-Hydroxyquinoline 是一种单质子二齿螯合剂,具有防腐、消毒和杀虫剂特性。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
50MG | ¥365 | 有现货 |
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100MG | ¥518 | 有现货 |
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200MG | ¥786 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Hydroxyquinoline
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述8-Hydroxyquinoline 是一种单质子二齿螯合剂,具有防腐、消毒和杀虫剂特性。
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产品描述8-Hydroxyquinoline is a monoprotic bidentate chelating agent, exhibits antiseptic, disinfectant, and pesticide properties, functioning as a transcription inhibitor.
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体外实验Cell Viability Assay Cell Line:DCIS cells Concentration:1,2.5,5,10,20 μM Incubation Time:1 or 8 hour Result:Binding to copper and form complexes make the cells rounded up and detached, induces cell death with in a concentration- and time-dependent manner. 8-OHQ- and CQ-Cu, but not mixture of their analogues and Cu, could induce cancer cell death in a concentration- and time-dependent manner. Western Blot Analysis Cell Line:DCIS cellsConcentration:1,2.5,5 μM.Incubation Time:0,2,4,8,12 hours Result:Mixture of CuCl2 inhibited the CT-like activity in a concentration- and time-dependent manner. Mixture of CuCl2 decreased proteasomal activity and increased ubquititinated proteins and Bax accumulated in a time-dependent manner. RT-PCR Cell Line:Lipopolysaccharides (HY-D1056)-stimulated Raw 264.7 cells Concentration:25,50,75,100 μM Incubation Time:30 min Result:Inhibited of LPS-induced NO and iNOS expression.Inhibits transcription of iNOS. Had not affect phosphorylation of MAPKs. Inhibited NF-jB-binding activity and C/EBPb-binding activity.
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体内实验Animal Model:CD1 mice Dosage:25,50,100 mg/kg Administration:Intraperitoneal injection (i.p.)Result:Resulted in a significant dose-related increase in the number of micronucleated polychromatic erythrocytes (MPCE) at the 24 h samplingtime for all doses tested. Animal Model:C57BL miceDosage:0.3% 4 times weekly.Administration:Skin administration Result:Caused depigmented hair to grow in patterns which change with time. Sufficiently frequent applications result in virtually complete depigmentation in young adult C57BL female mice, while single application causes isolated bands of depigmented hair.
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同义词Oxyquinoline | NSC 2039 | NSC-2039 | NSC2039
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通路Others
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靶点Other Targets
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受体Others
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研究领域Other Indications
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适应症——
化学信息
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CAS Number148-24-3
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分子量145.16
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分子式C9H7NO
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纯度>98% (HPLC)
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溶解度Water: 556 mg/l at 20 °C
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SMILESOC1=C2N=CC=CC2=CC=C1
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化学全称8-Hydroxyquinoline
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Freitas LB, et al. Eur J Med Chem. 2014 Sep 12;84:595-604.
产品手册




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