Hydroxyfasudil

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Hydroxyfasudil 是一种 ROCK 抑制剂（ROCK1 和 ROCK2 的 IC50 分别为 0.73 和 0.72 μM）。

Hydroxyfasudil is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).

Hydroxyfasudil is a ROCK inhibitor, with IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively. Hydroxyfasudil also less potently inhibits PKA, with an IC50 of 37 μM, 50-fold higher than those of the ROCKs. Hydroxyfasudil increases eNOS mRNA levels, with an EC50 value of 0.8 ± 0.3 μM. Hydroxyfasudil (0-100 μM) concentration-dependently increases eNOS activity and stimulates NO production in human aortic endothelial cells (HAEC). Hydroxyfasudil (10 μM) increases the half-life of eNOS mRNA from 13 to 16 hours, but does not affect eNOS promoter activity at concentrations from 0.1 to 100 μM.

Hydroxyfasudil (10 mg/kg, i.p.) significantly increases both the average and maximal voided volumes in SD rats. Hydroxyfasudil also significantly decreases the maximal detrusor pressure. Hydroxyfasudil (3 mg/kg, i.p) inhibits hypercontractility induced by norepinephrine in spontaneously hypertensive rats (SHRs). Furthermore, Hydroxyfasudil (3, 10 mg/kg, i.p) significantly ameliorates decreased penile cGMP contents in rats.

HA-1100 | Hydroxy-Fasudil

Apoptosis

PKA

PKA|ROCK|ROCK1|ROCK2

——

——

105628-72-6

307.37

C14H17N3O3S

>98% (HPLC)

DMSO:31 mg/mL (100.86 mM)

O=C1NC=CC2=C1C=CC=C2S(=O)(N3CCNCCC3)=O

——

(-20℃)

With Ice Pack

≥ 2 years