Hydroxybupropion

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Hydroxybupropion 是 Bupropion 的主要活性代谢产物，主要是通过 CYP2B6 代谢的。Bupropion 是一种非典型的抗抑郁剂和戒烟剂。Hydroxybupropion 抑制去甲肾上腺素 (norepinephrine uptake) 的摄取，IC50 值为 1.7 μM。Hydroxybupropion 也是一种 nACh 受体拮抗剂。

Hydroxybupropion is the active metabolite of Bupropion metabolized by CYP2B6. Bupropion is an antidepressant and smoking-cessation agent. Hydroxybupropion inhibits norepinephrine uptake (IC50: 1.7 μM). Hydroxybupropion is also a nACh receptor antagonist more potent than Bupropion.(In Vitro):Hydroxybupropion shows stronger antitetrabenazine activity and has a lower LD50 value than the erythro- and threo- metabolites. Hydroxybupropion inhibits norepinephrine and dopamine uptake, antagonizes nicotine, and shows antidepressant effects in rodents.

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6-Hydroxybupropion | Hydroxybupropion, (+/-)- | Hydroxybupropione

Others

Other Targets

PEGs

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92264-81-8

255.74

C13H18ClNO2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (391.02 mM)

CC(NC(C)(C)CO)C(=O)c1cccc(Cl)c1

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(-20℃)

With Ice Pack

≥ 2 years