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Histrelin
CAS No. 76712-82-8
Histrelin ( Supprelin LA )
产品货号. M24769 CAS No. 76712-82-8
醋酸组氨瑞林是促性腺激素释放激素 (GnRH) 的九肽类似物，具有更强的功效。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥697 | 有现货 |
|
| 5MG | ￥891 | 有现货 |
|
| 10MG | ￥1490 | 有现货 |
|
| 25MG | ￥2746 | 有现货 |
|
| 50MG | ￥4034 | 有现货 |
|
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Histrelin
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述醋酸组氨瑞林是促性腺激素释放激素 (GnRH) 的九肽类似物，具有更强的功效。
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产品描述Histrelin acetate is a nonapeptide analog of gonadotropin-releasing hormone (GnRH) with added potency. It is considered a GnRH agonist. Histrelin is used in the treatment of hormone-sensitive cancers of the prostate in men and uterine fibroids in women.
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体外实验Histrelin (10-100 nM) stimulates the release of vasopressin (VP) from from isolated rat hypothalamo-neurohypophysial explants.Histrelin (100 nM) stimulates oxytocin (OT) release from the rat hypothalamo-neurohypophysial system.
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体内实验Animal Model:Csfmop/Csfmop mice Dosage:0.001, 0.05, and 0.1 mg/kg Administration:Subcutaneous injection Result:Increased serum FSH concentrations by 4-fold.Animal Model:Rabbits Dosage:10, 30, or 100 μg /day Administration:Subcutaneous injection for 4 weeks Result:Caused a regression of the endometrial glands and a thinning of the stroma.
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同义词Supprelin LA
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number76712-82-8
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分子量1323.5
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分子式C66H86N18O12
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纯度>98% (HPLC)
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溶解度DMSO:Soluble; Water:Insoluble
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SMILESCCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC2=CN(C=N2)CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Lewis KA, Goldyn AK, West KW, Eugster EA. A single histrelin implant is effective for 2 years for treatment of central precocious puberty. J Pediatr. 2013 Oct;163(4):1214-6. doi: 10.1016/j.jpeds.2013.05.033. Epub 2013 Jul 1. PubMed PMID: 23809043.
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