Hispolon

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Hispolon 是一种多酚，可从桑黄 (Phellinus linteus) 中分离得到。Hispolon 具有抗癌、抗糖尿病、抗氧化、抗病毒、肝保护活性、抗糖尿病和抗炎活性。

Hispolon, a polyphenol, can be isolated from Phellinus linteus. Hispolon possesses anticancer, antidiabetic, antioxidant, antiviral, hepatoprotective, anti-diabetic, and anti-inflammatory activities.

Hispolon (25 and 50 μM, 24-72 h) inhibits cell viability of U87MG cells.Hispolon (25 and 50 μM, 24, 48 h) induces G2/M cell cycle arrest and apoptosis in U87MG cells.Hispolon (25 and 50 μM, 2-8 h) decreases the expression of G1–S transition-related protein cyclin D4 but increases the expression of CDK inhibitor p21.Hispolon (25 and 50 μM, 24 h) inhibits the migration of U87MG cells.Cell Viability Assay Cell Line:U87MG cells Concentration:25 and 50 μM Incubation Time:24, 48, 72 h Result:Inhibited cell viability in a dose and time dependent way.Western Blot Analysis Cell Line:U87MG cells Concentration:25 and 50 μM Incubation Time:2, 4, 8 h Result:Decreased cyclin D4 level, and increased p21 level.

Hispolon (2.5-10 mg/kg, i.p.) attenuates LPS-induced acute lung injury in mice.Hispolon (5 and 10 mg/kg, s.c.) reduces tumor growth in DBTRG xenograft mice.Animal Model:LPS-induced acute lung injury mice Dosage:2.5, 5 and 10 mg/kg Administration:Intraperitoneal injection (i.p.)Result:Alleviated the pathological effects in the LPS-challenged mouse.Reduced the W/D ratio in the lung and MPO activity.Decreased pro-Inflammatory cytokine production.Animal Model:DBTRG xenograft mice Dosage:5 and 10 mg/kg Administration:Subcutaneous injection (s.c.)Result:Reduced tumor volume (RTV).Inhibited GBM cell proliferation in vivo upon HE and ki-67 staining.

——

Others

Other Targets

Others

——

——

173933-40-9

220.22

C12H12O4

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 125 mg/mL (567.61 mM; 超声助溶 (<70°C)

CC(=O)\C=C(/O)\C=C\c1ccc(O)c(O)c1

——

(-20℃)

With Ice Pack

≥ 2 years