Hexachlorophene

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

六氯酚(Hexaclofen) 是一种有效的 KCNQ1/KCNE1 钾通道激活剂，EC50 为 4.61 ± 1.29 μM；也是 Wnt/β-连环蛋白信号传导的抑制剂。

Hexachlorophene(Hexachlorofen) is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 μM; also is an inhibitor of Wnt/beta-catenin signaling.

Hexachlorophene (0.1-10 μM approximately) increases the current amplitude of KCNQ1/KCNE1 with an EC50 value of 4.61 μM, and shortens the action potential.Hexachlorophene (10 μM) rescues the loss of function of the LQTs mutants caused by either impaired activation gating or PIP2 binding affinity in CHO cells.Hexachlorophene (0-50 μg/mL approximately, 30 min) has antibacterial activities against micrococcus sp., staphylococcus, staphylococcus epidermidis and streptococcus with IC50 values of 0.83 μg/mL, 1.5 μg/mL, 1.75 μg/mL, 1.3 μg/mL, respectively.Hexachlorophene (20 μM, 15 h) inhibits Wnt/β-catenin signaling through the Siah-1-mediated β-catenin degradation in HEK293 and HCT116 cells.Hexachlorophene (0-10 μM, 48 h) inhibits the growth of HCT116 cells.Hexachlorophene is a competitive inhibitor of SARS-CoV 3CL with an IC50 value of 5 μM, and can form hydrogen bonds with SARS-CoV 3CL with Ki value estimated to be 4 μM. Western Blot Analysis Cell Line:HEK293 cells Concentration:0-40 μM Incubation Time:15 h Result:Degraded β-catenin response transcription (CRT) induced by Wnt3a CM by promoting the degradation of β-catenin, with an IC50 value of 7.03 μM.Cell Proliferation Assay Cell Line:HCT116 colon cancer cells Concentration:0, 1.25, 2.5, 5, 10 μM.Incubation Time:48 hResult:Inhibited the growth of HCT116 cells in a concentration-dependent manner.

Hexachlorophene (tail immersion for 5 minutes, 1.25% w/v, one day prior to cercarial exposure) has inhibitory activity against Schistosoma mansoni infections in mice (exposed to WRAIR,Puerto Rican strain).Hexachlorophene has acute and subacute toxic effects with i.p. LD50 ranged between 21.8 mg/kg-40.0 mg/kg, and the oral LD50 varied from 57.6 to 87.0 mg/kg, respectively. Animal Model:Wistar rats (acute and subacute assays)Dosage:0-100 mg/kg approximately Administration:Intraperitoneal injection or oral administration Result:Displayed acute and subacute toxic effects with i.p. LD50 ranged between 21.8 mg/kg-40.0 mg/kg, and the oral LD50 varied from 57.6 to 87.0 mg/kg, respectively.

Nabac | NSC 9887 | NSC 49115

Cell Cycle/DNA Damage

Potassium Channel

D-LDH| GluDH| SDH

Other Indications

——

70-30-4

406.9

C13H6Cl6O2

>98% (HPLC)

Soluble in water

C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl

3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenol

(-20℃)

With Ice Pack

≥ 2 years