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Helenine

CAS No. 546-43-0

Helenine ( Alantolactone | NSC 302289 | NSC302289 )

产品货号. M18777 CAS No. 546-43-0

Alantolactone(Alant Camphor) 是一种倍半萜内酯,通过抑制信号转导子和转录激活子 3 (STAT3) 信号通路,对三阴性乳腺 Y MDA-MB-231 细胞具有潜在活性。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥405 有现货
10MG ¥527 有现货
25MG ¥1166 有现货
50MG ¥1887 有现货
100MG ¥3402 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Helenine
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Alantolactone(Alant Camphor) 是一种倍半萜内酯,通过抑制信号转导子和转录激活子 3 (STAT3) 信号通路,对三阴性乳腺 Y MDA-MB-231 细胞具有潜在活性。
  • 产品描述
    Alantolactone neuroprotective roles in traumatic brain injury via anti-inflammatory, anti-oxidative and anti-apoptosis pathways.(In Vitro):Alantolactone induces apoptosis in HepG2 cells in a dose-dependent manner. This Alantolactone-induced apoptosis is found to be associated with GSH depletion, inhibition of STAT3 activation, ROS generation, mitochondrial transmembrane potential dissipation, and increased Bax/Bcl-2 ratio and caspase-3 activation. Alantolactone decreases STAT3 translocation to the nucleus, its DNA-binding, and STAT3 target gene expression. Alantolactone significantly inhibits STAT3 activation with a marginal effect on MAPKs and on NF-κB transcription; however, this effect is not mediated by inhibiting STAT3 upstream kinases.Alantolactone induces activin/SMAD3 signaling in human colon adenocarcinoma HCT-8 cells. Alantolactone performs its antitumor effect by interrupting the interaction between Cripto-1 and the activin receptor type IIA in the activin signaling pathway.Alantolactone (5 μg/mL, 24 h) inhibits cell proliferation in colon adenocarcinoma HCT-8 cells. (In Vivo):It is found that the average tumor volume in the Alantolactone-treated mice is approximately 2.17-fold lower compared with that in the control mice. However the administration of Alantolactone does not affect the overall bodyweight during the experimental period, suggesting no apparent toxicity. Additionally, the average tumor weight is significantly lower in the Alantolactone-treated mice compared with the control mice. What’s more, the administration of Alantolactone results in a significant decrease in p-STAT3 and cyclin D1 expression in the tumor tissues.
  • 体外实验
    ——
  • 体内实验
    Animal Model:Female athymic BALB/c nude mice at the age of 6 weeks.Dosage:2.5 mg/kg.Administration:I.P. injection every 2 days.Result:Exhibited anti-cancer activity.
  • 同义词
    Alantolactone | NSC 302289 | NSC302289
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    546-43-0
  • 分子量
    232.33
  • 分子式
    C15H20O2
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : ≥ 100 mg/mL; 430.44 mM
  • SMILES
    [C@@H]1(CCC[C@]2(C1=C[C@H]1[C@@H](C2)OC(=O)C1=C)C)C
  • 化学全称
    4alphaH-Eudesma-5,11(13)-dien-12-oic acid, 8beta-hydroxy-, gamma-lactone (8CI)

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Shope RE. J Exp Med. 1966 Feb 1;123(2):213-27.
产品手册
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