
Hecogenin
CAS No. 467-55-0
Hecogenin ( Hocogenin )
产品货号. M21457 CAS No. 467-55-0
Hecogenin 是从龙舌兰剑麻中分离出来的类固醇皂苷。它是人 UDP-葡萄糖醛酸基转移酶的选择性抑制剂。 Hecogenin 具有广泛的药理活性,包括抗炎、抗真菌和胃保护作用。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥324 | 有现货 |
![]() ![]() |
10MG | ¥462 | 有现货 |
![]() ![]() |
25MG | ¥689 | 有现货 |
![]() ![]() |
50MG | ¥1037 | 有现货 |
![]() ![]() |
100MG | ¥1547 | 有现货 |
![]() ![]() |
200MG | 获取报价 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称Hecogenin
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述Hecogenin 是从龙舌兰剑麻中分离出来的类固醇皂苷。它是人 UDP-葡萄糖醛酸基转移酶的选择性抑制剂。 Hecogenin 具有广泛的药理活性,包括抗炎、抗真菌和胃保护作用。
-
产品描述Hecogenin is a steroid saponin isolated from Agave sisalana. It is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities including anti-inflammatory antifungal and gastroprotective effects.
-
体外实验——
-
体内实验Hecogenin (3.1-90 mg/kg; oral administration; for 15 hours; male Swiss mice) acutely administered, before ethanol, exhibits a potent gastroprotective effect. The Hecogenin pretreatment normalizes GSH levels and significantly reduces lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Hecogenin also decreases MPO release and significantly protects the gastric mucosa. Animal Model:Male Swiss mice (20-30 g) with ethanol Dosage:3.1 mg/kg, 7.5 mg/kg, 15 mg/kg, 30 mg/kg, 60 mg/kg and 90 mg/kg Administration:Oral administration; for 15 hours Result:Normalized GSH levels and significantly reduced lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Decreased MPO release and significantly protected the gastric mucosa.
-
同义词Hocogenin
-
通路Others
-
靶点Other Targets
-
受体UDP-glucuronosyltransferases
-
研究领域——
-
适应症——
化学信息
-
CAS Number467-55-0
-
分子量430.6
-
分子式C27H42O4
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMF : 16.67 mg/mL (38.71 mM)
-
SMILESC[C@@H]([C@@H]([C@H](C[C@H]1[C@H](CC2)[C@H](C3)[C@@](C)(CC4)[C@@H]2C[C@H]4O)O2)[C@@]1(C)C3=O)[C@@]21OC[C@H](C)CC1
-
化学全称(22R25R)-3beta-Hydroxy-5alpha-spirostan-12-one
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Uchaipichat V et al. Drug Metab Dispos. 2006 34(3):449-56.