Hecogenin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Hecogenin 是从龙舌兰剑麻中分离出来的类固醇皂苷。它是人 UDP-葡萄糖醛酸基转移酶的选择性抑制剂。 Hecogenin 具有广泛的药理活性，包括抗炎、抗真菌和胃保护作用。

Hecogenin is a steroid saponin isolated from Agave sisalana. It is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities including anti-inflammatory antifungal and gastroprotective effects.

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Hecogenin (3.1-90 mg/kg; oral administration; for 15 hours; male Swiss mice) acutely administered, before ethanol, exhibits a potent gastroprotective effect. The Hecogenin pretreatment normalizes GSH levels and significantly reduces lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Hecogenin also decreases MPO release and significantly protects the gastric mucosa. Animal Model:Male Swiss mice (20-30 g) with ethanol Dosage:3.1 mg/kg, 7.5 mg/kg, 15 mg/kg, 30 mg/kg, 60 mg/kg and 90 mg/kg Administration:Oral administration; for 15 hours Result:Normalized GSH levels and significantly reduced lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Decreased MPO release and significantly protected the gastric mucosa.

Hocogenin

Others

Other Targets

UDP-glucuronosyltransferases

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467-55-0

430.6

C27H42O4

>98% (HPLC)

In Vitro:?DMF : 16.67 mg/mL (38.71 mM)

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(22R25R)-3beta-Hydroxy-5alpha-spirostan-12-one

(-20℃)

With Ice Pack

≥ 2 years