HaloPROTAC3

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

VH285-PEG5-C6-Cl (HaloPROTAC 3) 由 E3 配体与 16 个原子相连的复合分子，连接子的接头为 Halogen 基团。VH285-PEG5-C6-Cl 包含基于 VH285 的 VHL 配体和基于 alkyl/ether linker。VH285-PEG4-C4-Cl 是一种高效的 GFP-HaloTag7 降解剂，DC50 为 19 nM。VH285-PEG4-C4-Cl 在浓度为 625 nM 时诱导 90% GFP-Halotag 降解。VH285-PEG4-C4-Cl 与 VHL 结合，IC50 为 0.54 μM。

VH285-PEG4-C4-Cl (HaloPROTAC 3) is a conjugate of ligands for E3 and 16-atom-length linker. The connector of linker is Halogen group. VH285-PEG4-C4-Cl incorporates the VH285 based VHL ligand and an alkyl/ether-based linker. VH285-PEG4-C4-Cl is a highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM. VH285-PEG4-C4-Cl is able to induce 90 % degradation of GFP-Halotag at 625 nM. VH285-PEG4-C4-Cl binds to VHL with an IC50 of 0.54 μM.

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PROTACs

E3 Ligase Ligand

Ligand for E3 Ligase

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1799506-07-2

799.42

C41H55ClN4O8S

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (125.09 mM; 超声助溶 )

[C@@H](C(=O)N1[C@H](C(NCC2=C(OCCOCCOCCOCCCCCCCl)C=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1)(C(C)C)N4C(=O)C=5C(C4)=CC=CC5

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(-20℃)

With Ice Pack

≥ 2 years