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HTHQ

CAS No. 148081-72-5

HTHQ ( HX-1171 | HX-1171 | HX-1171 | HTHQ )

产品货号. M18047 CAS No. 148081-72-5

HTHQ 是一种对苯二酚单烷基醚,是一种有效的抗氧化剂。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥243 有现货
10MG ¥381 有现货
25MG ¥494 有现货
50MG ¥624 有现货
100MG ¥786 有现货
200MG ¥1280 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    HTHQ
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    HTHQ 是一种对苯二酚单烷基醚,是一种有效的抗氧化剂。
  • 产品描述
    HX-1171, also known as HTHQ, is a lipid peroxidation inhibitor potentially for the treatment of hepatic fibrosis. HTHQ and vitamin E attenuated interleukin-1beta-induced iNOS protein expression in cultured hepatocytes, the potency of HTHQ being 10-times higher than that of vitamin E. HTHQ may prevent tumor production induced by AP and NaNO2 more effectively than ascorbic acid.(In Vitro):HTHQ (0-100 μM; 24 hours; PC12 cells) treatment increases cell viabilities in a dose-dependent manner.HTHQ (10 μM; 0.6-24 hours; PC12 cells) inhibits 3,4-L-Dihydroxyphenylalanine (L-DOPA) -induced phosphorylation of sustaines extracellular signal-regulated kinases (ERK1/2), p38 mitogen-activated protein kinase (MAPK), and c-Jun N-terminal kinase (JNK1/2). HTHQ also normalizes L-DOPA-reduced Bcl-2-associated death protein (Bad) phosphorylation and Bcl-2-associated X protein (Bax) expression, promoting cell survival.(In Vivo):HTHQ (50-200 mg/kg; oral administration; for 4 weeks; specific pathogen-free male Sprague Dawley rats) treatment significantly improves liver weight and serum chemistry level. HTHQ reduces hydroxyproline and malondialdehyde level in the liver. HTHQ treatment also reduces fibrotic septa. HTHQ administration shows reduced mRNA level of PDGF (Plateletderived growth factor) , α-SMA (α-smooth muscle actin) and TGF-β (transforming growth factor-β) than DMN-induced hepetic fibrosis animals in the liver tissue.
  • 体外实验
    HTHQ (0-100 μM; 24 hours; PC12 cells) treatment increases cell viabilities in a dose-dependent manner.HTHQ (10 μM; 0.6-24 hours; PC12 cells) inhibits 3,4-L-Dihydroxyphenylalanine (L-DOPA) -induced phosphorylation of sustaines extracellular signal-regulated kinases (ERK1/2), p38 mitogen-activated protein kinase (MAPK), and c-Jun N-terminal kinase (JNK1/2). HTHQ also normalizes L-DOPA-reduced Bcl-2-associated death protein (Bad) phosphorylation and Bcl-2-associated X protein (Bax) expression, promoting cell survival. Cell Viability Assay Cell Line:PC12 cells Concentration:0 μM, 1 μM, 10 μM, and 100 μM Incubation Time:24 hours Result:Reduced cell viability at 24 hours caused by both 100 and 200 μM L-DOPA was significantly attenuated.Western Blot Analysis Cell Line:PC12 cells Concentration:10 μM Incubation Time:0.6-24 hours Result:Inhibited L-DOPA-induced phosphorylation of sustained extracellular signal-regulated kinases (ERK1/2), p38 mitogen-activated protein kinase (MAPK), and c-Jun N-terminal kinase (JNK1/2). And also normalized L-DOPA-reduced Bcl-2-associated death protein (Bad) phosphorylation and Bcl-2-associated X protein (Bax) expression.
  • 体内实验
    HTHQ (50-200 mg/kg; oral administration; for 4 weeks; specific pathogen-free male Sprague Dawley rats) treatment significantly improves liver weight and serum chemistry level. HTHQ reduces hydroxyproline and malondialdehyde level in the liver. HTHQ treatment also reduces fibrotic septa. HTHQ administration shows reduced mRNA level of PDGF (Plateletderived growth factor) , α-SMA (α-smooth muscle actin) and TGF-β (transforming growth factor-β) than DMN-induced hepetic fibrosis animals in the liver tissue. Animal Model:48 specific pathogen-free male Sprague Dawley (SD) rats (6-week-old ) with dimethylnitrosamine (DMN) Dosage:50 mg/kg, 100 mg/kg, 200 mg/kg Administration:Oral administration; for 4 weeks Result:Improved against DMN-induced liver fibrosis in male SD rats.
  • 同义词
    HX-1171 | HX-1171 | HX-1171 | HTHQ
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    Others-Field
  • 适应症
    ——

化学信息

  • CAS Number
    148081-72-5
  • 分子量
    236.35
  • 分子式
    C15H24O2
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : ≥ 100 mg/mL; 423.10 mM
  • SMILES
    CCCCCCOc1c(c(c(c(c1)C)O)C)C
  • 化学全称
    4-(hexyloxy)-2,3,6-trimethylphenol

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Hino T, et al. Biochim Biophys Acta. 1998 Sep 16;1425(1):47-60.
产品手册
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