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HT-0712
CAS No. 617720-02-2
HT-0712 ( IPL-455903 )
产品货号. M15336 CAS No. 617720-02-2
HT-0712 (IPL-455903) is a novel potent, selective PDE4 inhibitor with IC50 of 0.15 uM for PDE4D3.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥9477 | 有现货 |
|
| 50MG | ￥19278 | 有现货 |
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| 100MG | ￥25110 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称HT-0712
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述HT-0712 (IPL-455903) is a novel potent, selective PDE4 inhibitor with IC50 of 0.15 uM for PDE4D3.
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产品描述HT-0712 (IPL-455903) is a novel potent, selective PDE4 inhibitor with IC50 of 0.15 uM for PDE4D3, without effect on PDE1B, PDE3A, and PDE10A; facilitates expression of a CRE-luciferase reporter gene and expression of the CREB target-gene somatostatin in SK-N-MC neuroblastoma cells, abolishes the long-term memory defect of CBP+/- mice, enhances long-term memory formation in normal young mice at brain concentrations similar to those found to increase CRE-mediated gene expression in hippocampal neurons.Alzheimer Disease Phase 2 Clinical
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同义词IPL-455903
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通路Angiogenesis
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靶点PDE
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受体PDE
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研究领域Neurological Disease
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适应症Alzheimer Disease
化学信息
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CAS Number617720-02-2
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分子量393.53
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分子式C25H31NO3
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C1NC[C@H](C2=CC=C(OC)C(OC3CCCC3)=C2)C[C@H]1CC4=CC=CC(C)=C4
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化学全称(3S,5S)-5-(3-(cyclopentyloxy)-4-methoxyphenyl)-3-(3-methylbenzyl)piperidin-2-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Peters M, et al. Neuropsychopharmacology. 2014 Dec;39(13):2938-48.
2. MacDonald E, et al. Neurorehabil Neural Repair. 2007 Nov-Dec;21(6):486-96.
3. Bourtchouladze R, et al. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10518-22.
2. MacDonald E, et al. Neurorehabil Neural Repair. 2007 Nov-Dec;21(6):486-96.
3. Bourtchouladze R, et al. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10518-22.
产品手册
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