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HS271
CAS No. 2410393-15-4
HS271 ( —— )
产品货号. M28114 CAS No. 2410393-15-4
HS271 is a highly potent, orally active and selective IRAK4 inhibitor, with an IC50 of 7.2 μM. HS271 exhibits superior enzymatic and cellular activities, as well as excellent pharmacokinetic properties.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2341 | 有现货 |
|
| 10MG | ￥3872 | 有现货 |
|
| 25MG | ￥6391 | 有现货 |
|
| 50MG | ￥8748 | 有现货 |
|
| 100MG | ￥11988 | 有现货 |
|
| 500MG | ￥24057 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称HS271
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述HS271 is a highly potent, orally active and selective IRAK4 inhibitor, with an IC50 of 7.2 μM. HS271 exhibits superior enzymatic and cellular activities, as well as excellent pharmacokinetic properties.
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产品描述HS271 is a highly potent, orally active and selective IRAK4 inhibitor, with an IC50 of 7.2 μM. HS271 exhibits superior enzymatic and cellular activities, as well as excellent pharmacokinetic properties.(In Vivo):In rat models of LPS-induced TNFα production collagen-induced arthritis, HS271 (15-150 mg/kg) shows robust antiinflammatory efficacy with a t1/2 of 3.3 h and Cmax of 2107 ng/mL. The oral bioavailability of HS271 is 67.3%, 58.2%, 14.4&% and 49% in mice, rats, dogs, and monkeys, respectively.
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同义词——
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通路Others
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靶点Other Targets
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受体G2019S LRRK2;LRRK2
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研究领域——
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适应症——
化学信息
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CAS Number2410393-15-4
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分子量435.4
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分子式C21H24F3N5O2
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纯度>98% (HPLC)
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溶解度——
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SMILESN/A
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Nigel Ramsden, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.
产品手册
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