HS-1371

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

HS-1371 (HS1371) 是一种新型有效的 ATP 竞争性受体相互作用蛋白激酶 3（RIP3 或 RIPK3 激酶）抑制剂，IC50 为 20.8 nM。

HS-1371 (HS1371) is a novel potent, ATP-competitive receptor-interacting protein kinase-3 (RIP3 or RIPK3 kinase) inhibitor with IC50 of 20.8 nM; binds to the ATP binding pocket of RIP3 and inhibits ATP binding to prevent RIP3 enzymatic activity in vitro; inhibits S227 auto-phosphorylation of RIP3 in treated HT-29 cells, blocks necrosome complex formation, rescues cells from RIP3-dependent necroptotic cell death but not apoptotic cell death.

HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner. HS-1371 has an inhibitory effect on RIP3 kinase activity in various cell lines.HS-1371 (0.1, 1, 5, 10, 20 μM, 9 h) can block RIP3 S227 phosphorylation.HS-1371(0.1, 1, 5, 10 μM, 24 h) rescues cells from RIP3-dependent necroptotic cell death but not apoptotic cell death. Western Blot AnalysisCell Line:HT-29 cells?Concentration:0.1, 1, 5, 10, 20 μM Incubation Time:9 hours Result:Showed an inhibitory effect on S227 auto-phosphorylation of RIP3.

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HS1371 | HS 1371

Apoptosis

RIP kinase

RIP kinase

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2158197-70-5

384.483

C24H24N4O

>98% (HPLC)

DMSO : 16.67 mg/mL 43.36 mM

CC1=CC=C(OC2=CC=NC3=CC(C4=CN(C5CCNCC5)N=C4)=CC=C23)C=C1

7-(1-(Piperidin-4-yl)-1H-pyrazol-4-yl)-4-(p-tolyloxy)quinoline

(-20℃)

With Ice Pack

≥ 2 years