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HOIPIN-8
CAS No. ——
HOIPIN-8 ( HOIP inhibitor-8 )
产品货号. M17006 CAS No. ——
HOIPIN-8（HOIP抑制剂-8）是线性泛素链组装复合物（LUBAC，IC50=11 nM）的有效化学抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称HOIPIN-8
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述HOIPIN-8（HOIP抑制剂-8）是线性泛素链组装复合物（LUBAC，IC50=11 nM）的有效化学抑制剂。
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产品描述HOIPIN-8 (HOIP inhibitor-8) is a potent chemical inhibitor of linear ubiquitin chain assembly complex (LUBAC, IC50=11 nM), specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the NF-kB pathway; suppresses the linear ubiquitination activity by recombinant LUBAC, displays 255-fold increased potency over that of HOIPIN-1 (JTP-0819958, IC50=2.8 uM); also shows 10-fold and 4-fold enhanced inhibitory activities on LUBAC- and TNF-a-induced NF-kB activation respectively, without cytotoxicity; HOIPIN-8 is a powerful tool to explore the physiological functions of LUBAC.
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体外实验——
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体内实验——
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同义词HOIP inhibitor-8
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通路Proteasome/Ubiquitin
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靶点E3 Ubiquitin Ligase
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受体E3 Ubiquitin Ligase
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研究领域——
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适应症——
化学信息
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CAS Number——
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分子量456.385
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分子式C23H15F2N4NaO3
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称Sodium (E)-2-(3-(2,6-difluoro-4-(1H-pyrazol-4-yl)phenyl)-3-oxoprop-1-en-1-yl)-4-(1-methyl-1H-pyrazol-4-yl)benzoate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Katsuya K, et al. Biochem Biophys Res Commun. 2019 Jan 2. pii: S0006-291X(18)32846-8.
