HLY-78

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Wnt/β-连环蛋白信号通路的激活剂，靶向 Axin 的 DIX 结构域。

An activator of the Wnt/β-catenin signaling pathway that targets the DIX domain of Axin; potentiates the Axin-LRP6 association, thus promoting LRP6 phosphorylation and Wnt signaling transduction; acts synergistically with Wnt in the embryonic development of zebrafish and increases the expression of the conserved hematopoietic stem cell (HSC) markers, runx1 and cmyb, in zebrafish embryos.

HLY78 inhibits apoptosis in tumor cells and embryonic cells caused by carbon ion radiation through activation of the Wnt/β-catenin pathway.HLY78 (20 μM, 0-48 h) significantly increases the colony formation ability by 2.78-fold and 2.88-fold for HGC-27 and AGS cells compared with the controls.HLY78 (20 μM, 0-48 h) elevates the migration ability of HGC-27 and AGS cells.HLY78 significantly increases TNKS expression, which is ameliorated by Dihydroartemisinin (HY-N0176).

HLY78 (0-1.8 mg/kg, Intranasal injection, once) attenuates neuronal apoptosis and improves neurological deficits through the LRP6/GSK3β/β-catenin signaling pathway after SAH (subarachnoid hemorrhage) in rats. Animal Model:Adult male Sprague-Dawley rats (280-310 g, n=9/group, SAH model)Dosage:0, 0.2, 0.6, and 1.8 mg/kg Administration:Intranasal injection, once, at 1 h post-SAH (subarachnoid hemorrhage)Result:Significantly attenuated the short-term and long-term neurobehavioral deficits, as well as the neuronal apoptosis after SAH at 0.6 mg/kg. Successfully delivered into the brain via intranasal administration at 0.6 mg/kg and was sufficient to significantly increase the phosphorylation of LRP6. Reversed the changes of the Bcl-2, Bax, and cleaved caspase 3 levels.

HLY78 | HLY 78

Wnt/Notch/Hedgehog

Axin

Axin

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854847-61-3

267.3

C17H17NO2

>98% (HPLC)

In Vitro:?DMSO : 26 mg/mL (97.26 mM)

CCC1=C2C(=CC=C1)C3=CC4=C(C=C3CN2C)OCO4

4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine

(-20℃)

With Ice Pack

≥ 2 years