HJC0152

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种有效的、口服生物可利用的 STAT3 信号传导抑制剂，在体外和体内表现出有希望的抗肿瘤作用。

A potent, orally bioavailable STAT3 signaling inhibitor that exhibits promising antitumor effects in vitro and in vivo via inactivating STAT3 and downstream miR-21/β-catenin axis; potently inhibits MCF-7, MDA-MB-231, AsPC1 and Panc-1a cell with IC50 of 0.91, 1.64, 1.9 and 1.08 uM, respectively; suppresses HNSCC cell proliferation, arrests the cell cycle at the G0-G1 phase, induces apoptosis and reduces cell invasion in both SCC25 and CAL27 cell lines; inhibits nuclear translocation of phosphorylated STAT3 at Tyr705 and decreases VHL/β-catenin signaling activity via regulation of miR-21; suppresses MDA-MB-231 xenograft tumor growth in vivo.

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HJC-0152 | HJC 0152

JAK/STAT Signaling

STAT

STAT3

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1420290-99-8

406.644

C15H14Cl3N3O4

>98% (HPLC)

DMSO: 82 mg/mL (201.7 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )

O=C(NC1=CC=C([N+]([O-])=O)C=C1Cl)C2=CC(Cl)=CC=C2OCCN.[H]Cl

2-(2-aminoethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide hydrochloride

(-20℃)

With Ice Pack

≥ 2 years