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HC-067047
CAS No. 883031-03-6
HC-067047 ( HC-067047; HC 067047; HC067047 )
产品货号. M19226 CAS No. 883031-03-6
HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH .
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥502 | 有现货 |
|
| 10MG | ￥794 | 有现货 |
|
| 25MG | ￥1604 | 有现货 |
|
| 50MG | ￥2657 | 有现货 |
|
| 100MG | ￥4277 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称HC-067047
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH .
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产品描述HC-067047 is a potent and selective TRPV4 antagonist. HC-067047 increases functional bladder capacity and reduces micturition frequency in WT mice and rats with cystitis. HC-067047 did not affect bladder function in Trpv4(-/-) mice, demonstrating that its in vivo effects are on target. HC-067047 may provide a promising means of treating bladder
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同义词HC-067047; HC 067047; HC067047
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通路Others
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靶点Other Targets
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受体hTRPV4/mTRPV4
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研究领域Cancer
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适应症——
化学信息
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CAS Number883031-03-6
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分子量471.51
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分子式C26H28F3N3O2
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纯度98%
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溶解度DMSO : 50 mg/mL 106.04 mM;
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SMILESFC(F)(F)c1cc(ccc1)NC(=O)c4cc(c2ccccc2)n(CCCN3CCOCC3)c4C
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化学全称2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Everaerts W et al. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis.Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19084-9.
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