• 咨询热线
    客服服务热线 13671568941/15317326293
  • 在线咨询
  • 微信客服
    微信客服
  • 公众号
    扫码关注公众号

Glycerite

CAS No. 1401-55-4

Glycerite ( Tannic acid | NSC 656273 | NSC-656273 )

产品货号. M11675 CAS No. 1401-55-4

多酚化合物,分子量约为 500-3000 道尔顿,含有足够的羟基(每 100 MW 1-2 个),可有效交联其他化合物(收敛剂)。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
500MG ¥332 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Glycerite
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    多酚化合物,分子量约为 500-3000 道尔顿,含有足够的羟基(每 100 MW 1-2 个),可有效交联其他化合物(收敛剂)。
  • 产品描述
    Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS). The two main types are HYDROLYZABLE TANNINS and CONDENSED TANNINS. Historically, the term has applied to many compounds and plant extracts able to render skin COLLAGEN impervious to degradation. The word tannin derives from the Celtic word for OAK TREE which was used for leather processing. (In Vivo):During the course of treatment, tannic acid significantly ameliorates these phenotypes in AD skin lesions. Tannic acid treatment aslo reduces these dermal changes compare with AD mice. Treatment with tannic acid increases PPARγ expression in AD skin sections. The PPARγ protein expression is suppressed in vehicle-treated AD mice, but when treats with tannic acid, its expression is increased dramatically. The IL-1β, TNFα, TNFR1, and COX2 protein expressions are significantly up-regulated in vehicle-treated AD mice, but significantly suppressed by tannic acid treatment.
  • 体外实验
    ——
  • 体内实验
    During the course of treatment, tannic acid significantly ameliorates these phenotypes in AD skin lesions. Tannic acid treatment aslo reduces these dermal changes compare with AD mice. Treatment with tannic acid increases PPARγ expression in AD skin sections. The PPARγ protein expression is suppressed in vehicle-treated AD mice, but when treats with tannic acid, its expression is increased dramatically. The IL-1β, TNFα, TNFR1, and COX2 protein expressions are significantly up-regulated in vehicle-treated AD mice, but significantly suppressed by tannic acid treatment.
  • 同义词
    Tannic acid | NSC 656273 | NSC-656273
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1401-55-4
  • 分子量
    1701.2
  • 分子式
    C76H52O46
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: 10 mM
  • SMILES
    OC1=C(O)C(O)=CC(C(OC2=CC(C(OCC3C(OC(C4=CC(O)=C(O)C(OC(C5=CC(O)=C(O)C(O)=C5)=O)=C4)=O)C(OC(C6=CC(O)=C(O)C(OC(C7=CC(O)=C(O)C(O)=C7)=O)=C6)=O)C(OC(C8=CC(O)=C(O)C(OC(C9=CC(O)=C(O)C(O)=C9)=O)=C8)=O)C(OC(C%10=CC(O)=C(O)C(OC(C%11=CC(O)=C(O)C(O)=C%11)=O)=C%10)=O)O3)=O)=CC(O)=C2O)=O)=C1
  • 化学全称
    6-(((3,4-dihydroxy-5-((3,4,5-trihydroxybenzoyl)oxy)benzoyl)oxy)methyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetrakis(3,4-dihydroxy-5-((3,4,5-trihydroxybenzoyl)oxy)benzoate)

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.JENKINS JT. Am J Surg. 1947 Oct;74(4):428-30.
产品手册
关联产品
  • Methyl 2,4-dihydroxy...

    2,4-二羟基苯乙酸甲酯是从大马士革黑种草种子中分离出来的天然产物,具有选择性植物毒性作用。

  • Cromoglicic acid

    色甘酸是一种具有抗炎活性的肥大细胞稳定剂,可防止肥大细胞释放炎症化学物质,如组胺、白三烯。

  • Glicoricone

    Glicoricone acts as a partial estrogen antagonist. Glicoricone inhibited the monoamine oxidase with the IC50 values of 6.0 x 10(-5)-1.4 x 10(-4) M.