Gigantol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells.

Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a promising neuroprotective agent for successful MSC transplantation in ischemic diseases, it shows the protective effect against hydrogen peroxide-induced apoptosis in rat bone marrow mesenchymal stem cells through the PI3K/Akt pathway.Gigantol inhibits aldose reductase gene to exert its anti-cataract activity. Gigantol induces growth inhibition and apoptosis of HepG2 cells via the PI3K/Akt/NF-κB signaling pathway.Gigantol also shows α-glucosidase inhibitory activity.

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Others

Other Targets

β-catenin; α-glucosidase

Cancer

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67884-30-4

274.31

C16H18O4

98%

DMSO : ≥ 160 mg/mL; 583.28 mM

COc1cc(O)cc(CCc2ccc(OC)c(O)c2)c1

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(-20℃)

With Ice Pack

≥ 2 years